{"id":"W2913803346","doi":"10.1002/mds.27614","title":"The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Neurological Disorders and Stroke; Medical Research Council; Barts Charity; Parkinson's UK; Rosetrees Trust; Michael J. Fox Foundation for Parkinson's Research; National Institutes of Health; U.S. Department of Health and Human Services; U.S. Department of Defense","keywords":"Mendelian randomization; Endocytic cycle; Heritability; Biology; Genome-wide association study; Genetics; Mendelian inheritance; Gene; Genetic association; Bioinformatics; Genotype; Single-nucleotide polymorphism; Endocytosis; Cell; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003762781,0.0002222223,0.0002596668,0.00008270617,0.0001444833,0.00003045925,0.0002296495,0.00003741197,0.0001070856],"category_scores_gemma":[0.0000590364,0.0001241427,0.0002167583,0.0002202813,0.00005735028,0.0000592706,0.00004360755,0.0001572025,0.00003431783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008682128,"about_ca_system_score_gemma":0.0001102147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002385838,"about_ca_topic_score_gemma":0.0003138719,"domain_scores_codex":[0.9983154,0.0001444461,0.0002945508,0.0003237099,0.0005280925,0.0003937888],"domain_scores_gemma":[0.9989256,0.0001911397,0.0001552486,0.0005839011,0.00002166674,0.0001224515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00237918,0.003529855,0.9409307,0.0003116198,0.0008798333,0.000134027,0.002959361,0.00101113,0.00185192,0.006421376,0.0003562909,0.03923477],"study_design_scores_gemma":[0.01339787,0.0007106646,0.9072714,0.0002417917,0.0007018048,8.305862e-7,0.009172999,0.007508812,0.002123774,0.01965306,0.03880818,0.0004087474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929716,0.001997067,0.00002861271,0.001012938,0.0001119926,0.001473325,0.00007058992,0.00002726367,0.002306613],"genre_scores_gemma":[0.9977057,0.0007231815,0.00002923837,0.0009999997,0.0000221231,0.0002203929,0.00003191318,0.00002625152,0.0002411914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03882602,"threshold_uncertainty_score":0.5062394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006021927460952957,"score_gpt":0.2171533449519313,"score_spread":0.2111314174909784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}