{"id":"W2913816372","doi":"10.1002/chin.201303101","title":"ChemInform Abstract: Discovery of a Potent, Orally Bioavailable and Highly Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitor, N‐(1‐(Piperidin‐4‐yl)indolin‐5‐yl)thiophene‐2‐carboximidamide as a Pre‐Clinical Development Candidate for the Treatment of Migraine.","year":2013,"lang":"en","type":"article","venue":"ChemInform","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeurAxon (Canada)","funders":"","keywords":"Chemistry; Bioavailability; Neuronal Nitric Oxide Synthase; Pharmacology; Thiophene; Nitric oxide synthase; Nitric oxide; Orally active; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714533,0.0007325439,0.0003048919,0.000402017,0.0002518225,0.0003344281,0.000326635,0.0003514485,0.00588948],"category_scores_gemma":[0.0001446764,0.0001875095,0.0001832697,0.0002470762,0.0002132219,0.0002553814,0.0002005562,0.0005011865,0.001466419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793229,"about_ca_system_score_gemma":0.0006959069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008921373,"about_ca_topic_score_gemma":0.001784075,"domain_scores_codex":[0.9999443,0.000008351488,0.000002640576,0.00001192216,0.00002030607,0.00001249311],"domain_scores_gemma":[0.9999553,0.000005923196,0.00001016927,0.00000272425,0.00001083283,0.00001503776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00252735,0.001220026,0.0008233826,0.001596482,0.0001017212,0.0009850502,0.0001145485,0.001867295,0.8657963,0.002852322,0.01415185,0.1079637],"study_design_scores_gemma":[0.001997913,0.00857527,0.004639958,0.0001111459,0.0002128243,0.002269813,0.00004451418,0.001832666,0.9091909,0.0005120115,0.07056484,0.00004815073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8376971,0.03475569,0.01823248,0.002700371,0.0006348523,0.001309827,0.007871795,0.0009700958,0.09582788],"genre_scores_gemma":[0.9281475,0.02291101,0.008971495,0.0009070364,0.0002284851,0.0002538843,0.006421647,0.00005613179,0.03210285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00588948,"threshold_uncertainty_score":0.01970226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733794713012888,"score_gpt":0.2977358840023608,"score_spread":0.270397936872232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}