{"id":"W2913828105","doi":"10.1186/s12931-019-0992-3","title":"Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling","year":2019,"lang":"en","type":"article","venue":"Respiratory Research","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Institute of Population and Public Health; Institute of Circulatory and Respiratory Health; National Institute for Occupational Safety and Health; Institute of Infection and Immunity; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; Oregon State University; Iowa State University; University of Saskatchewan","keywords":"HMGB1; Inflammation; Rage (emotion); Signal transduction; Airway; Immunology; Chemistry; Cell biology; Medicine; Biology; Neuroscience; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469354,0.0005477468,0.0003861322,0.0003137265,0.0001332641,0.0003165292,0.000293747,0.0003921537,0.002072642],"category_scores_gemma":[0.0001289257,0.0001254095,0.0003525275,0.0001435899,0.0002353217,0.000246112,0.0002143618,0.0005658449,0.0003361713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694849,"about_ca_system_score_gemma":0.0002366662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004414856,"about_ca_topic_score_gemma":0.000760025,"domain_scores_codex":[0.9998997,0.00002161377,0.000008742993,0.00001488573,0.00002019832,0.00003491292],"domain_scores_gemma":[0.9998949,0.000009847236,0.00003866141,0.000009461103,0.00001340729,0.00003387279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004246149,0.0008139744,0.0006078779,0.0002444811,0.00003662398,0.00007138652,0.00001860732,0.00012352,0.9889042,0.00005414805,0.0001335984,0.004745345],"study_design_scores_gemma":[0.000402839,0.009468315,0.01327003,0.00003672235,0.0001008104,0.0001942303,0.0001295783,0.0008127062,0.9721187,0.00008278692,0.00337258,0.00001061549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927754,0.004217392,0.001272724,0.0002391134,0.0001154258,0.00004585109,0.0003545189,0.0001272245,0.0008523896],"genre_scores_gemma":[0.9928684,0.002395077,0.00123587,0.0001027493,0.00003324861,0.0000548724,0.0005030327,0.00001268307,0.002793972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072642,"threshold_uncertainty_score":0.00693363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04371656823335521,"score_gpt":0.3566022816257401,"score_spread":0.3128857133923849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}