{"id":"W2913833109","doi":"10.1172/jci.insight.122442","title":"CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Public Health Agency; Queen's University Belfast; Fight for Sight UK; Queen's University; British Heart Foundation","keywords":"Angiogenesis; Neovascularization; Choroidal neovascularization; Signal transduction; Vascular endothelial growth factor; Retina; Retinal; Cancer research; Cell biology; Growth factor; Gene isoform; Downregulation and upregulation; Vascular endothelial growth factor A; Biology; Neuroscience; Receptor; VEGF receptors; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547529,0.0002356934,0.0002573343,0.0002279861,0.0002054015,0.0002703838,0.0002594705,0.0002731435,0.001202301],"category_scores_gemma":[0.00008997134,0.00008339188,0.0001666077,0.0001428554,0.0002477818,0.0002011551,0.0001666094,0.000937219,0.0002140087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000636347,"about_ca_system_score_gemma":0.0004039149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008155548,"about_ca_topic_score_gemma":0.002038072,"domain_scores_codex":[0.9999251,0.00001143835,0.000004717884,0.00001140452,0.00002375139,0.00002346807],"domain_scores_gemma":[0.9999729,0.000003295248,0.000007572874,0.000003004208,0.000003780212,0.000009370087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002834924,0.0001169533,0.0003172471,0.0003041494,0.00001593998,0.0002032912,0.0000279785,0.0001653643,0.9703861,0.002595115,0.0007409413,0.02484333],"study_design_scores_gemma":[0.0004211058,0.001651384,0.009268579,0.0001209359,0.00009159827,0.002274506,0.00008125512,0.003032271,0.9192585,0.001553992,0.06222764,0.00001810156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7936895,0.1513813,0.0189992,0.004647585,0.001317657,0.0003724292,0.0004747977,0.0003544124,0.02876315],"genre_scores_gemma":[0.9675497,0.0214743,0.005778864,0.0003842128,0.0001081194,0.0001017166,0.0001835239,0.00001592279,0.004403654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202301,"threshold_uncertainty_score":0.004617095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669148825673208,"score_gpt":0.2741808679260203,"score_spread":0.2574893796692883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}