{"id":"W2913833109","doi":"10.1172/jci.insight.122442","title":"CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Public Health Agency; Queen's University Belfast; Fight for Sight UK; Queen's University; British Heart Foundation","keywords":"Angiogenesis; Neovascularization; Choroidal neovascularization; Signal transduction; Vascular endothelial growth factor; Retina; Retinal; Cancer research; Cell biology; Growth factor; Gene isoform; Downregulation and upregulation; Vascular endothelial growth factor A; Biology; Neuroscience; Receptor; VEGF receptors; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000313669,0.0001399653,0.0002124761,0.00005572696,0.00005794456,0.00002805343,0.00003527263,0.00007932857,0.0002187401],"category_scores_gemma":[0.00003370289,0.0001030516,0.0001129876,0.00008200501,0.00001617975,0.00008190198,0.00001597131,0.00006500536,0.00007197693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000407957,"about_ca_system_score_gemma":0.00006483001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005362427,"about_ca_topic_score_gemma":0.000001370795,"domain_scores_codex":[0.9992318,0.00002207912,0.0001317717,0.0002555703,0.0001851502,0.0001736511],"domain_scores_gemma":[0.9995272,0.00003240283,0.00004988994,0.0001735238,0.00009112839,0.0001259012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003857376,0.001376722,0.8579091,0.0009936991,0.00154145,0.0001435568,0.001862146,0.000002275355,0.09461976,0.01845575,0.0003942628,0.01884384],"study_design_scores_gemma":[0.008407079,0.00402644,0.9473476,0.0001426707,0.0005104044,0.00008340492,0.00009464624,0.0007200165,0.01463311,0.002568012,0.02111312,0.0003534508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932631,0.0006870747,0.0001957553,0.000501547,0.0001278713,0.0009291447,0.00001202966,0.00003667132,0.004246816],"genre_scores_gemma":[0.9977848,0.00007906904,0.0002851337,0.0004142667,0.00009741668,0.00003979104,0.000106894,0.00002626708,0.001166363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08943849,"threshold_uncertainty_score":0.4202321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669148825673208,"score_gpt":0.2741808679260203,"score_spread":0.2574893796692883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}