{"id":"W2913880687","doi":"10.1101/543355","title":"Targeted enhancement of flotillin-dependent endocytosis augments cellular uptake and impact of cytotoxic drugs","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Toronto Metropolitan University; Toronto Zoo","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science","keywords":"Internalization; Endocytosis; Endocytic cycle; Cisplatin; Cancer research; Cytotoxic T cell; Nanocarriers; Cancer; Pharmacology; Medicine; Drug; Chemistry; Cell; In vitro; Internal medicine; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181039,0.0001845805,0.0001660138,0.0001413058,0.0001125555,0.0002083039,0.000135099,0.000238864,0.001477981],"category_scores_gemma":[0.0001060502,0.0000650763,0.0001442035,0.00007310417,0.0001617631,0.0001483581,0.0001730126,0.0003109616,0.000328055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096278,"about_ca_system_score_gemma":0.0001569773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007891968,"about_ca_topic_score_gemma":0.0008367985,"domain_scores_codex":[0.9999229,0.000009882934,0.000003136347,0.00000990065,0.00002595761,0.0000282173],"domain_scores_gemma":[0.9999582,0.00001446178,0.00000655268,0.000005060815,0.000007828154,0.000007950793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005174711,0.00001643131,0.00004119116,0.0000218133,0.00000218891,0.00002694068,0.00000421746,0.00006917023,0.998953,0.0001549462,0.00005164382,0.0006066593],"study_design_scores_gemma":[0.000004540978,0.00002796918,0.0004784707,0.000001531488,0.000001767128,0.00002867623,0.000002482647,0.0004526101,0.9981517,0.00002349991,0.0008255088,0.000001160247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906588,0.001602474,0.003868449,0.0001729495,0.00003931007,0.00003484384,0.0001975021,0.00008634697,0.003339394],"genre_scores_gemma":[0.9917709,0.0005748362,0.002206508,0.00007406084,0.00001091191,0.00002175583,0.000237698,0.00003235004,0.005071006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477981,"threshold_uncertainty_score":0.004944384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007889100669321872,"score_gpt":0.2213475335402962,"score_spread":0.2134584328709743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}