{"id":"W2913892166","doi":"10.1101/538157","title":"Structural and binding studies of human CAMKK2 kinase domain bound to small molecule ligands","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Science; National Institutes of Health; Ministero dello Sviluppo Economico; Universidade Estadual de Campinas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Argonne National Laboratory; U.S. Department of Energy; National Institute of General Medical Sciences; Diamond Light Source; Novartis Pharma; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Pfizer; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA","keywords":"Protein kinase A; Isothermal titration calorimetry; Kinase; Small molecule; Biochemistry; Chemistry; AMPK; Protein kinase domain; Cell biology; CAMK; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513233,0.000485188,0.0003454119,0.0001596535,0.0003600785,0.0002127411,0.0006006738,0.0003471981,0.002161209],"category_scores_gemma":[0.0002378914,0.0001597696,0.0003188204,0.0002342372,0.0002110915,0.0001794499,0.0001674877,0.0008323067,0.0003372483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007488999,"about_ca_system_score_gemma":0.0002610268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004446195,"about_ca_topic_score_gemma":0.00348757,"domain_scores_codex":[0.9998559,0.00002568895,0.000006638669,0.00003232131,0.00004470028,0.00003466314],"domain_scores_gemma":[0.9999175,0.00002356012,0.00001520225,0.000005222286,0.00001542624,0.00002301106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001051755,0.0001913939,0.00115476,0.0002151119,0.0000749029,0.0004093897,0.0001205194,0.005090246,0.9878325,0.0004324788,0.0009319981,0.002494926],"study_design_scores_gemma":[0.0001245662,0.0004468835,0.008485813,0.00002261895,0.00008430674,0.0005002411,0.0001290199,0.02576336,0.9586702,0.0001413718,0.005594385,0.00003718126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940311,0.002080511,0.001604264,0.00017026,0.0000477747,0.00001546516,0.0005474563,0.00003983716,0.001463382],"genre_scores_gemma":[0.9946494,0.0007662585,0.001446891,0.00007664401,0.000009935981,0.00001643628,0.001404409,0.0000136129,0.00161645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004446195,"threshold_uncertainty_score":0.00884068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984982641108033,"score_gpt":0.2571683729808663,"score_spread":0.2373185465697859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}