{"id":"W2913931318","doi":"10.1101/528901","title":"Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer’s disease and three causality networks of AD: the GR@ACE project","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Eisai; Northern California Institute for Research and Education; Instituto de Salud Carlos III; Illinois Department of Public Health; Rush University; Servier; Universitat Autònoma de Barcelona; CurePSP; Corporación Tecnológica de Andalucía; Pfizer; Biogen; BioClinica; Mayo Foundation for Medical Education and Research; Grifols; F. Hoffmann-La Roche; European Federation of Pharmaceutical Industries and Associations; Mayo Clinic; GlaxoSmithKline; Alzheimer's Drug Discovery Foundation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Translational Genomics Research Institute; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Junta de Andalucía; Novartis Pharmaceuticals Corporation; Foundation for the National Institutes of Health; European Commission; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Endophenotype; Genome-wide association study; Disease; Dementia; Genetic association; Genetics; Genetic architecture; Biology; Phenotype; Bioinformatics; Medicine; Genotype; Gene; Computational biology; Neuroscience; Single-nucleotide polymorphism; Pathology; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006836722,0.001671528,0.002218065,0.003185728,0.0009211277,0.003061962,0.001616074,0.001085874,0.002977033],"category_scores_gemma":[0.01028998,0.0005566656,0.008981274,0.005063288,0.0007259474,0.0005724326,0.002644301,0.001380938,0.0003613123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006187161,"about_ca_system_score_gemma":0.001069331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01743186,"about_ca_topic_score_gemma":0.01769574,"domain_scores_codex":[0.9933358,0.002793766,0.000581548,0.00214861,0.000673149,0.0004670161],"domain_scores_gemma":[0.9872909,0.006306743,0.001988342,0.002554109,0.001037666,0.0008221936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005082548,0.00008441464,0.9014313,0.0008866221,0.06667219,0.000941855,0.0001968071,0.001840207,0.003088957,0.0007018653,0.002010038,0.01706325],"study_design_scores_gemma":[0.0003710339,0.0002624716,0.9339179,0.0002317574,0.05549003,0.0009641659,0.0002273819,0.003861215,0.001068905,0.001465594,0.002078192,0.00006131871],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626247,0.01716514,0.00617965,0.001163843,0.0001077807,0.00006050216,0.01063639,0.000183446,0.00187863],"genre_scores_gemma":[0.9905811,0.001929993,0.002950222,0.0001744147,0.00007574728,0.00004671851,0.00383064,0.00005440259,0.0003568915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01743186,"threshold_uncertainty_score":0.03615648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.043637720679503,"score_gpt":0.2998201921546153,"score_spread":0.2561824714751123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}