{"id":"W2913946693","doi":"10.1038/s41467-019-08798-7","title":"PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Caprion (Canada); Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; McGill University; Canadian Foundation for AIDS Research; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Delaney AIDS Research Enterprise; Styrelsen för Internationellt Utvecklingssamarbete; Medical Research Council; amfAR, The Foundation for AIDS Research","keywords":"Blockade; Monoclonal antibody; Ex vivo; Cytotoxic T cell; Immune system; Latency (audio); Immunology; T-cell receptor; T cell; Biology; Virology; Immune checkpoint; Antibody; Pembrolizumab; Jurkat cells; Immunotherapy; Cancer research; Medicine; In vivo; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148089,0.0002795873,0.0004079186,0.0001879927,0.0002101837,0.00032749,0.0002369907,0.0002635183,0.001705719],"category_scores_gemma":[0.000223119,0.0001596526,0.0001927822,0.00009209562,0.0001700588,0.0001411246,0.0001986498,0.001003929,0.0003870398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001166789,"about_ca_system_score_gemma":0.0002119823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003144937,"about_ca_topic_score_gemma":0.0004686411,"domain_scores_codex":[0.9998491,0.00003848142,0.000009931106,0.00001810623,0.00002264477,0.00006171144],"domain_scores_gemma":[0.9998674,0.00003453422,0.00001502909,0.00001332633,0.000008340077,0.00006131449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004036659,0.001478277,0.001144234,0.00007043196,0.00003068996,0.0001403148,0.00005929574,0.0002994042,0.9791631,0.0001272265,0.0003917165,0.01305856],"study_design_scores_gemma":[0.002168087,0.04481202,0.03314557,0.00004370429,0.0001940411,0.001044057,0.0001102939,0.004005114,0.9091055,0.0003028722,0.005044101,0.00002463875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977851,0.0005483802,0.0003355805,0.00008494969,0.00004347259,0.00003868421,0.0001082782,0.00003959179,0.001015892],"genre_scores_gemma":[0.9979183,0.0002400135,0.000426323,0.0001050521,0.00005222818,0.00004654286,0.0002164759,0.00000948699,0.0009856521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705719,"threshold_uncertainty_score":0.005706131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057911511534305,"score_gpt":0.2642323021201677,"score_spread":0.2536531870048247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}