{"id":"W2913947277","doi":"10.1101/548974","title":"Blood and Brain Gene Expression Trajectories Underlying Neuropathology and Cognitive Impairment in Neurodegeneration","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; IXICO; Servier; National Institutes of Health; Bristol-Myers Squibb; Canada First Research Excellence Fund; Eisai; Northern California Institute for Research and Education; H. Lundbeck A/S; Illinois Department of Public Health; Rush University; McGill University; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neuropathology; Neurodegeneration; Neuroscience; Neurology; Neuroimaging; Disease; Population; Cognition; Biology; Medicine; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003550813,0.000266828,0.0002076875,0.0005607215,0.0001252252,0.0003967813,0.0001803584,0.0002205372,0.0006671116],"category_scores_gemma":[0.001098708,0.00008964292,0.0002567089,0.0004289224,0.000187196,0.0001872317,0.0002410052,0.0003194606,0.0001654957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612182,"about_ca_system_score_gemma":0.0002530811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00287465,"about_ca_topic_score_gemma":0.003383785,"domain_scores_codex":[0.9999008,0.0000268471,0.000005646791,0.00004230915,0.00001322891,0.00001118528],"domain_scores_gemma":[0.9995976,0.0001480099,0.0001353544,0.00004240505,0.00004546188,0.00003110881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009177625,0.0001263938,0.8800431,0.00007551681,0.0003100791,0.0001887563,0.0001283595,0.01536932,0.05212887,0.0006661183,0.000739433,0.04930624],"study_design_scores_gemma":[0.00001456097,0.0001360767,0.8949731,0.00002366569,0.00011725,0.0003799511,0.00009898985,0.08777432,0.01226636,0.003369222,0.0008220522,0.00002451503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879622,0.0003171997,0.01006998,0.00006892004,0.000005991523,0.000008531165,0.001183858,0.00007599308,0.0003074117],"genre_scores_gemma":[0.9950905,0.0001272986,0.003441463,0.00001972859,0.000008165457,0.00001142919,0.001025767,0.00001057499,0.000265015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00287465,"threshold_uncertainty_score":0.005715907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675714123215988,"score_gpt":0.2510230521421042,"score_spread":0.2242659109099443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}