{"id":"W2913988913","doi":"10.1101/525691","title":"Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; Tongji Medical College, Huazhong University of Science and Technology; National Institutes of Health; Tongji University; Huazhong University of Science and Technology","keywords":"Biology; Transduction (biophysics); Haematopoiesis; Progenitor cell; Stem cell; Myeloid; Enhancer; Rhesus macaque; Cancer research; Viral vector; Virology; Transcription factor; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772406,0.0002183501,0.000170894,0.0002728587,0.0002341698,0.0002447487,0.00009424092,0.0003342792,0.0004175661],"category_scores_gemma":[0.0002039004,0.00008895699,0.000136425,0.0001049106,0.000412082,0.00009876394,0.0002346125,0.0005204647,0.0001525781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758679,"about_ca_system_score_gemma":0.0002039626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571799,"about_ca_topic_score_gemma":0.001646931,"domain_scores_codex":[0.9998608,0.00002220725,0.00001101207,0.00003035933,0.000044922,0.00003070155],"domain_scores_gemma":[0.9998533,0.00003075067,0.00003704021,0.00003888739,0.00001534142,0.00002465077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006640382,0.00002158336,0.001625791,0.00002119596,0.00000745271,0.002660439,0.000106383,0.00008989817,0.9920776,0.0002583026,0.00004961482,0.003015313],"study_design_scores_gemma":[0.00001693119,0.0005889192,0.02808204,0.0000115711,0.00005216413,0.02765667,0.0001265318,0.003104645,0.9349203,0.0003800557,0.005049383,0.00001079404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971226,0.0002883052,0.001645736,0.00005896908,0.000006434146,0.00002488877,0.00006419837,0.00007020746,0.0007186125],"genre_scores_gemma":[0.997331,0.000207776,0.001340089,0.0000423487,0.000005690659,0.00001500144,0.00009435031,0.0000229997,0.0009408167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571799,"threshold_uncertainty_score":0.00312525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502122737018004,"score_gpt":0.2544642106338416,"score_spread":0.2394429832636616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}