{"id":"W2914004109","doi":"10.1016/s1470-2045(18)30779-4","title":"Endpoint selection in HER2-positive early breast cancer","year":2019,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Surrogate endpoint; Breast cancer; Clinical endpoint; Oncology; Internal medicine; Clinical trial; Cancer; Disease; Trastuzumab; Stage (stratigraphy)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03872576,0.0006935761,0.002604046,0.0007443378,0.001106975,0.002806042,0.001859439,0.01172431,0.003233511],"category_scores_gemma":[0.08899519,0.0005023436,0.001312386,0.001303127,0.001718241,0.001744589,0.001254251,0.01350946,0.001760202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002617589,"about_ca_system_score_gemma":0.002603862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001812416,"about_ca_topic_score_gemma":0.003827995,"domain_scores_codex":[0.9670433,0.02676799,0.001916571,0.0007929631,0.002642453,0.0008368079],"domain_scores_gemma":[0.9076432,0.08037496,0.002599866,0.002734799,0.003431721,0.003215509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01092182,0.0003489777,0.01759034,0.0007217929,0.000300181,0.001654179,0.0002644169,0.0004934326,0.0008780416,0.01141583,0.7961997,0.1592113],"study_design_scores_gemma":[0.01016601,0.003935966,0.04205837,0.0027971,0.001102227,0.003858574,0.0005494658,0.004520867,0.00380612,0.1460698,0.78087,0.000265507],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008454066,0.01981422,0.002245917,0.9179828,0.04009864,0.0001379862,0.001095276,0.00006595858,0.01010512],"genre_scores_gemma":[0.05624997,0.00873111,0.002294443,0.8343183,0.09003964,0.0007840717,0.0005955871,0.00008699811,0.006899842],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03872576,"threshold_uncertainty_score":0.2048038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673488801735562,"score_gpt":0.296237161298312,"score_spread":0.2795022732809563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}