{"id":"W2914013737","doi":"10.1093/ecco-jcc/jjy222.537","title":"P413 A simple scoring tool predicts exposure–response relationship, onset of action, response to interval shortening, and surgical risk with vedolizumab therapy for Crohn’s disease","year":2019,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cohort; Vedolizumab; Medicine; Internal medicine; Cohort study; Disease; Surgery; Crohn's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002852626,0.0008092279,0.0009902291,0.001513728,0.0002015901,0.001130847,0.0003805671,0.0006190853,0.002662408],"category_scores_gemma":[0.01038093,0.0001857468,0.001092289,0.0009892588,0.0002276507,0.0005969771,0.0007688884,0.0006695116,0.0007844113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611073,"about_ca_system_score_gemma":0.0004201689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008589632,"about_ca_topic_score_gemma":0.001082047,"domain_scores_codex":[0.9980305,0.0007355222,0.0002473171,0.0002634535,0.000580364,0.000142859],"domain_scores_gemma":[0.9904165,0.004703491,0.003083804,0.0003839349,0.0008017696,0.0006105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003594287,0.0002380392,0.9253922,0.0001303047,0.0003761014,0.0001137188,0.0000588573,0.005664671,0.001527659,0.0001508012,0.001977957,0.06077539],"study_design_scores_gemma":[0.0004340488,0.003704001,0.881722,0.00007829253,0.0003034637,0.001026798,0.00009052933,0.1057533,0.002753997,0.0007637776,0.003287201,0.00008256968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987996,0.0006425374,0.005402801,0.0002712995,0.00004136671,0.0001172425,0.002673463,0.0002288731,0.002626378],"genre_scores_gemma":[0.992932,0.0001356095,0.004691953,0.00006059422,0.00003734159,0.00007161975,0.001591583,0.00001204647,0.0004674214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002852626,"threshold_uncertainty_score":0.01508635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175704681179609,"score_gpt":0.2675332616923967,"score_spread":0.2557762148806006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}