{"id":"W2914057743","doi":"10.1002/chin.200814142","title":"ChemInform Abstract: Substituted Phenanthrene Imidazoles as Potent, Selective, and Orally Active mPGES‐1 Inhibitors.","year":2008,"lang":"en","type":"article","venue":"ChemInform","topic":"Organic Chemistry Cycloaddition Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Phenanthrene; Orally active; Combinatorial chemistry; Stereochemistry; Pharmacology; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006464295,0.0005325848,0.0004371295,0.00008515081,0.0004662812,0.00007084895,0.0003347123,0.0004760932,0.007550386],"category_scores_gemma":[0.000381188,0.0005480025,0.0001713058,0.0003504135,0.0004808653,0.000783329,0.0001743855,0.0006925887,0.0002458316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004795129,"about_ca_system_score_gemma":0.0004483792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001352665,"about_ca_topic_score_gemma":0.00001719179,"domain_scores_codex":[0.997696,7.261464e-8,0.0006138003,0.0005550758,0.000494956,0.0006400237],"domain_scores_gemma":[0.9979762,0.0001139751,0.0006581747,0.0005488276,0.0002657971,0.0004370607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001779663,0.0002858561,0.0002910019,0.0002991738,0.0002380627,0.000106414,0.001303621,3.747951e-7,0.8315768,0.00005479136,0.04644732,0.1192187],"study_design_scores_gemma":[0.001217991,0.000008463352,0.001743897,0.00008952836,0.00005227163,0.00097185,0.0007999281,0.000003793903,0.9541407,0.00007443782,0.04028363,0.0006135149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.3859674,0.00008371266,8.723344e-8,0.0001409735,0.00007844037,0.00009656593,0.0001335566,0.0003059726,0.6131933],"genre_scores_gemma":[0.9785273,0.0005002686,0.00003358415,0.0000764693,0.0005080221,0.00007324417,0.0006876023,0.0000640621,0.01952944],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5936639,"threshold_uncertainty_score":0.9996971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030425028566065,"score_gpt":0.2214437975595697,"score_spread":0.2111395472739091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}