{"id":"W2914088338","doi":"10.1182/blood-2018-176","title":"Resistance to Lenalidomide in Del(5q) MDS Is Mediated By Inhibition of Drug-Induced Megakaryocytic Differentiation","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"RUNX1; Cancer research; Lenalidomide; Biology; Immunology; Molecular biology; Medicine; Haematopoiesis; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009167199,0.0001256992,0.0001551395,0.0001845859,0.00007841239,0.0002426232,0.0000696632,0.0001315399,0.0009449742],"category_scores_gemma":[0.0001337828,0.00007007756,0.0001353715,0.0000959162,0.00009380858,0.00005366709,0.0001100258,0.0001539286,0.0002064979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420014,"about_ca_system_score_gemma":0.00004674554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951709,"about_ca_topic_score_gemma":0.0004522889,"domain_scores_codex":[0.9999208,0.00001890005,0.00001054498,0.00001473533,0.00001913382,0.00001582749],"domain_scores_gemma":[0.9999524,0.00001123549,0.00001612475,0.000006946122,0.000004473643,0.000008714102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003192132,0.00002175814,0.00959326,0.00002680926,0.00001737933,0.000167881,0.00003549493,0.0001190529,0.985617,0.00006557057,0.00006824239,0.003948292],"study_design_scores_gemma":[0.00007307654,0.001303877,0.3516643,0.00002038332,0.00008062696,0.003363993,0.0001356198,0.00225542,0.632373,0.0001210961,0.00859902,0.000009529555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984428,0.000727566,0.0002257354,0.00003059662,0.000002836911,0.000007399236,0.0001011679,0.00001246682,0.0004493142],"genre_scores_gemma":[0.9992466,0.0001635556,0.000142024,0.00001817515,0.00000195548,0.000004516815,0.0001560627,0.000002457273,0.0002647791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009449742,"threshold_uncertainty_score":0.003161252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540397433459698,"score_gpt":0.2805320959159446,"score_spread":0.2651281215813476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}