{"id":"W2914098214","doi":"10.1016/s0140-6736(19)30038-8","title":"Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Stroke Association; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Blood pressure; Modified Rankin Scale; Stroke (engine); Thrombolysis; Clinical endpoint; Contraindication; Internal medicine; Clinical trial; Surgery; Anesthesia; Myocardial infarction; Ischemia; Ischemic stroke","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00263167,0.001996343,0.003382647,0.0003206371,0.0004467702,0.001574267,0.001066479,0.001812034,0.007587431],"category_scores_gemma":[0.003061999,0.0004510298,0.002644445,0.0004384339,0.001152769,0.001528164,0.0007442782,0.003874189,0.001006304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008789892,"about_ca_system_score_gemma":0.001264378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226137,"about_ca_topic_score_gemma":0.002898171,"domain_scores_codex":[0.9988679,0.000597813,0.00007882937,0.000185604,0.00009685623,0.0001730583],"domain_scores_gemma":[0.9987878,0.0004316324,0.0002905472,0.0001357687,0.00007878863,0.0002754348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9851133,0.001765421,0.0003532075,0.000772202,0.001425973,0.00002907385,0.00004178505,0.0001704503,0.0008180949,0.0001841304,0.001178913,0.008147469],"study_design_scores_gemma":[0.988583,0.009083441,0.001072214,0.00004021863,0.000464962,0.0000182611,0.00001165508,0.0001399547,0.0001027844,0.0001499434,0.0003217741,0.00001187934],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971639,0.009849179,0.001982999,0.001872362,0.001192501,0.00441322,0.003026901,0.0002875814,0.00573629],"genre_scores_gemma":[0.963647,0.005873196,0.005192658,0.004698144,0.001214515,0.008974906,0.00372928,0.00008635323,0.006584018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007587431,"threshold_uncertainty_score":0.02538252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05274394254593238,"score_gpt":0.3594013724385853,"score_spread":0.3066574298926529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}