{"id":"W2914141586","doi":"10.1172/jci.insight.126742","title":"β Cell tone is defined by proglucagon peptides through cAMP signaling","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institute on Aging; American Diabetes Association","keywords":"Proglucagon; Paracrine signalling; Glucose homeostasis; Endocrinology; Internal medicine; Insulin; Islet; Glucagon receptor; Autocrine signalling; Biology; Receptor; Signal transduction; Glucagon; Glucagon-like peptide-1; Cell biology; Secretion; Insulin resistance; Type 2 diabetes; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116732,0.0003359583,0.0002225301,0.0002762058,0.000228273,0.0008028785,0.0002091128,0.0002204617,0.00104131],"category_scores_gemma":[0.0001284775,0.0001111219,0.0001909337,0.0001307427,0.0005092679,0.0003848136,0.0003095076,0.0009075129,0.0003176596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058645,"about_ca_system_score_gemma":0.000167015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000317372,"about_ca_topic_score_gemma":0.0002812913,"domain_scores_codex":[0.9999217,0.00001467905,0.000006247555,0.00001938124,0.00001598305,0.00002212341],"domain_scores_gemma":[0.9999037,0.00001501267,0.00002285291,0.00001234428,0.000009596734,0.00003638678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003626453,0.00001665157,0.001424082,0.00007870894,0.000007269615,0.000542469,0.00008753152,0.00003473965,0.9878898,0.001608408,0.0001765287,0.007771196],"study_design_scores_gemma":[0.00007749685,0.0007818997,0.05547396,0.0000855846,0.00007123574,0.005107642,0.0004534077,0.0008498801,0.9029379,0.004687311,0.02944542,0.00002827617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94548,0.02282909,0.009633329,0.001345491,0.0003261716,0.00003162464,0.0004395326,0.0002395147,0.01967525],"genre_scores_gemma":[0.9858173,0.008712368,0.002600023,0.0003556601,0.0001371982,0.00002378276,0.0001461877,0.00002800507,0.002179592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104131,"threshold_uncertainty_score":0.003483593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152451666745685,"score_gpt":0.2562772880276148,"score_spread":0.2410321213530464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}