{"id":"W2914143970","doi":"10.1002/chin.200543129","title":"Inhibitors of the Inducible Microsomal Prostaglandin E<sub>2</sub> Synthase (mPGES‐1) Derived from MK‐886","year":2005,"lang":"en","type":"article","venue":"ChemInform","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Microsome; ATP synthase; Prostaglandin E2; Prostaglandin; Biochemistry; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447163,0.0004659804,0.0002797145,0.0002278386,0.0001229401,0.0002283893,0.0001954334,0.000220792,0.002866777],"category_scores_gemma":[0.0001420687,0.0001631203,0.0002759481,0.0001364728,0.0001859133,0.0001820207,0.0001760307,0.0008779131,0.0009179867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468374,"about_ca_system_score_gemma":0.0003737392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004067204,"about_ca_topic_score_gemma":0.0009510081,"domain_scores_codex":[0.9999052,0.00001774334,0.000008830995,0.00001202456,0.0000243727,0.00003191211],"domain_scores_gemma":[0.9999548,0.000009137889,0.00001245775,0.000005076518,0.000005513504,0.00001298534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002171296,0.0003364494,0.0002216771,0.0003404579,0.00005433157,0.0001156105,0.00002692965,0.0006630544,0.9811953,0.0009038827,0.001179057,0.01279182],"study_design_scores_gemma":[0.0004749081,0.002080173,0.001788939,0.00001849284,0.00005895066,0.0002725713,0.00001750542,0.000935286,0.9820264,0.0001788641,0.01213695,0.00001097866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588811,0.01124924,0.01054561,0.00081921,0.0005179401,0.0003025316,0.0020845,0.0004121119,0.01518785],"genre_scores_gemma":[0.97755,0.007072891,0.004438252,0.0001739121,0.00007333138,0.0001983542,0.001932348,0.00003505218,0.00852578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002866777,"threshold_uncertainty_score":0.009590328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007955631782358082,"score_gpt":0.2172650755606714,"score_spread":0.2093094437783133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}