{"id":"W2914170473","doi":"10.1101/537886","title":"Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; Enhancer; Gene; Genetics; PAX8; Chromatin immunoprecipitation; Chromatin; Gene knockdown; Transcription factor; Cancer research; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009581153,0.0001765577,0.0001531077,0.0004146166,0.000124811,0.0002089365,0.0001035214,0.0001663023,0.001799707],"category_scores_gemma":[0.0001947245,0.0001070139,0.0001563287,0.0003243162,0.0001347795,0.00008864199,0.0002536127,0.0001522127,0.0002306201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001193432,"about_ca_system_score_gemma":0.00009519961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004415925,"about_ca_topic_score_gemma":0.0008694863,"domain_scores_codex":[0.9998883,0.00001294476,0.000007483265,0.00002889223,0.00004099449,0.00002137686],"domain_scores_gemma":[0.9999121,0.00002324061,0.00003131673,0.000009566113,0.00000763067,0.00001602302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000686306,0.00003783798,0.09307104,0.0001820925,0.000125751,0.001339774,0.00008989198,0.0009794878,0.8755094,0.0006342945,0.0002517405,0.02709232],"study_design_scores_gemma":[0.00006359838,0.0002730047,0.8092731,0.0000542769,0.000202828,0.007204855,0.0002064636,0.005823399,0.1684195,0.001460338,0.007001095,0.00001761204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972529,0.0006972355,0.0007750334,0.00002534483,0.000004726778,0.000007473363,0.0003682804,0.00004156129,0.0008274433],"genre_scores_gemma":[0.9989616,0.0001441208,0.0002481792,0.000016519,0.000002264987,0.000004959024,0.0003027528,0.000006255196,0.0003134303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001799707,"threshold_uncertainty_score":0.006020606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353653954674493,"score_gpt":0.2439609171278408,"score_spread":0.2304243775810959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}