{"id":"W2914211667","doi":"","title":"Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway","year":2018,"lang":"en","type":"article","venue":"Nottingham ePrints (University of Nottingham)","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Farnesoid X receptor; Bile acid; FGF19; Fibroblast growth factor; Gut flora; Fecal bacteriotherapy; Downregulation and upregulation; Transplantation; Biology; Receptor; Internal medicine; Endocrinology; Microbiology; Immunology; Biochemistry; Medicine; Clostridium difficile; Nuclear receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001133315,0.0003651857,0.0006159873,0.000605041,0.0003868815,0.00004345424,0.0003181893,0.0003120073,0.0002226657],"category_scores_gemma":[0.0006202108,0.000334095,0.0002500667,0.001195079,0.000348459,0.0001852701,0.00008186758,0.0006985409,0.00003133262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006240708,"about_ca_system_score_gemma":0.0002599921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002187491,"about_ca_topic_score_gemma":0.003326487,"domain_scores_codex":[0.9971966,0.0003954631,0.0004419984,0.0007501711,0.0005720395,0.0006437882],"domain_scores_gemma":[0.9977794,0.0008073084,0.0003607448,0.0003278366,0.000591898,0.000132762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005925881,0.002195548,0.1316333,0.0008474046,0.0002511992,0.00009370749,0.01789846,0.00002453468,0.8277915,0.00006247017,0.0002779166,0.01299816],"study_design_scores_gemma":[0.00853829,0.003057871,0.4386513,0.002100081,0.0001227302,0.00001799026,0.00197197,0.0009382715,0.5438004,0.00002731883,0.0002926856,0.000481163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959192,0.00002656416,0.0008021444,0.000352313,0.00007158071,0.002034819,0.0002584618,0.00006934545,0.0004655647],"genre_scores_gemma":[0.9989176,0.00007678777,0.0004600732,0.0000625716,0.0001342908,0.00001809149,0.0002214717,0.0000404081,0.00006875167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.307018,"threshold_uncertainty_score":0.9999111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077282494137471,"score_gpt":0.2542557997007405,"score_spread":0.2334829747593658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}