{"id":"W2914232272","doi":"10.1007/s11523-018-00617-1","title":"Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies","year":2019,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre","funders":"Boehringer Ingelheim","keywords":"Medicine; Nausea; Proteinuria; Adverse effect; Peripheral edema; Internal medicine; Vomiting; Dosing; Pharmacodynamics; Pharmacokinetics; Gastroenterology; Pharmacology; Oncology; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009912362,0.001232024,0.001301852,0.0003808904,0.0003301471,0.0005995421,0.0006727743,0.0006147077,0.002187142],"category_scores_gemma":[0.0004623796,0.0003825748,0.000572112,0.0004069415,0.0004505902,0.0004489868,0.0003086204,0.001670762,0.0005933195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006274831,"about_ca_system_score_gemma":0.001038336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000847122,"about_ca_topic_score_gemma":0.002487573,"domain_scores_codex":[0.999759,0.0001008116,0.0000131838,0.00003849429,0.00003150708,0.00005692614],"domain_scores_gemma":[0.999688,0.00005019321,0.00006437417,0.00002222566,0.00002219971,0.0001529953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2909061,0.09638848,0.03611322,0.001684196,0.001981185,0.001011877,0.001044449,0.008545019,0.2206175,0.0007280468,0.01066922,0.3303108],"study_design_scores_gemma":[0.2644172,0.6510839,0.05692464,0.00007061425,0.0007527281,0.001309848,0.0001037217,0.004553745,0.01363909,0.0003219873,0.006777914,0.00004468645],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925195,0.002790001,0.000656267,0.0002268163,0.00003460196,0.001652785,0.000552645,0.000109051,0.001458383],"genre_scores_gemma":[0.9931854,0.001376001,0.001667707,0.0004427257,0.00005098933,0.0009865991,0.001287309,0.00001615937,0.0009869247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002187142,"threshold_uncertainty_score":0.007316709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02749436018870834,"score_gpt":0.3522023992081704,"score_spread":0.3247080390194621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}