{"id":"W2914253295","doi":"10.1038/s41598-018-36265-8","title":"Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Cell biology; Oxidative phosphorylation; Biogenesis; Phosphorylation; Mitochondrial biogenesis; Gene; Mitochondrion; Biology; Gene expression; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722035,0.0003009436,0.0003037332,0.0002572987,0.0001729351,0.000306641,0.0001114122,0.0001537363,0.001735548],"category_scores_gemma":[0.0001478709,0.0001669214,0.0002228005,0.0001759048,0.000248077,0.00008308802,0.0001935788,0.0005771396,0.0004279877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497892,"about_ca_system_score_gemma":0.000222754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005970943,"about_ca_topic_score_gemma":0.0006365876,"domain_scores_codex":[0.9998404,0.00003167627,0.00001754946,0.00003942344,0.00003856036,0.0000323543],"domain_scores_gemma":[0.9999104,0.00002027562,0.00002504168,0.00001141741,0.0000117932,0.00002114773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001825304,0.00001893493,0.0002850719,0.00005623434,0.00000720162,0.00005790841,0.00001459319,0.0000305089,0.9982803,0.00007162487,0.0001634969,0.0008315352],"study_design_scores_gemma":[0.00004472069,0.0003850122,0.01432153,0.00001042512,0.0000357434,0.0006100681,0.00003922475,0.0007957752,0.9785156,0.00008052849,0.005156911,0.00000455086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838206,0.008046323,0.003429107,0.0003892939,0.0001678157,0.00004962075,0.00127399,0.0001827807,0.002640622],"genre_scores_gemma":[0.9908327,0.003057319,0.00229036,0.0001175657,0.00003288646,0.00007825374,0.001131861,0.00003023688,0.002428837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001735548,"threshold_uncertainty_score":0.005805969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868984568462095,"score_gpt":0.2219363860169314,"score_spread":0.2132465403323104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}