{"id":"W2914282788","doi":"10.1172/jci96313","title":"Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":427,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Ontario Institute for Cancer Research; McGill University Health Centre; Montreal Neurological Institute and Hospital; University of Toronto; Centre Hospitalier de l’Université de Montréal; McGill University; Princess Margaret Cancer Centre; Occupational Cancer Research Centre","funders":"Merck Sharp and Dohme; National Cancer Institute; National Institutes of Health; University of Toronto; Québec Consortium for Drug Discovery; Ohio State University; McGill University Health Centre; Stand Up To Cancer; Faculty of Medicine, McGill University; McGill University; Deutsches Krebsforschungszentrum","keywords":"Stromal cell; Tumor microenvironment; Granzyme B; Triple-negative breast cancer; Immune system; Cancer research; CD8; Cytotoxic T cell; Biology; Granzyme; Laser capture microdissection; Immune checkpoint; Immunology; Breast cancer; Immunotherapy; Cancer; Gene expression; Perforin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292472,0.0001299131,0.0001577517,0.0005788041,0.0001339601,0.0004011366,0.00007513048,0.0001671394,0.000506388],"category_scores_gemma":[0.0001794838,0.00009058048,0.0001013642,0.000203016,0.0001725612,0.0001280156,0.0002255333,0.0001958671,0.0001082959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314888,"about_ca_system_score_gemma":0.000140735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008043841,"about_ca_topic_score_gemma":0.001788153,"domain_scores_codex":[0.9999158,0.00001511629,0.000006083201,0.00001989346,0.00001936762,0.00002377768],"domain_scores_gemma":[0.9999048,0.00001443022,0.0000422461,0.000007675448,0.00001098103,0.00002001807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001051793,0.00004870059,0.2047968,0.00006906412,0.00004488165,0.0004119508,0.0002677584,0.000771034,0.7777473,0.000406056,0.0002033057,0.01418125],"study_design_scores_gemma":[0.00002587393,0.0003158005,0.8914517,0.00002167748,0.00007947083,0.002363754,0.000805604,0.003885434,0.09783892,0.0007231373,0.002462906,0.00002579797],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979079,0.0005230747,0.000808972,0.00002551465,0.000003415502,0.00001149211,0.0001149336,0.00001779584,0.0005868223],"genre_scores_gemma":[0.9991332,0.0001087562,0.0004441783,0.00001871477,0.000004121327,0.000007968347,0.00009362759,0.000002603566,0.0001868999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008043841,"threshold_uncertainty_score":0.001694083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03719470121437023,"score_gpt":0.3412165992050687,"score_spread":0.3040218979906985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}