{"id":"W2914290722","doi":"10.1016/j.msec.2019.02.030","title":"Functionalizing the surface of hydroxyapatite drug carrier with carboxylic acid groups to modulate the loading and release of curcumin nanoparticles","year":2019,"lang":"en","type":"article","venue":"Materials Science and Engineering C","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Australian Research Council","keywords":"Curcumin; Carboxylic acid; Nanoparticle; Bioavailability; Materials science; Citric acid; Tartaric acid; Adsorption; Cancer cell; Apoptosis; Drug delivery; Nuclear chemistry; Biophysics; Nanotechnology; Chemistry; Organic chemistry; Biochemistry; Pharmacology; Cancer; Polymer chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001475034,0.0001312531,0.0002037708,0.00006076889,0.0001396137,0.0001227158,0.0002569827,0.00001833558,0.00003344319],"category_scores_gemma":[0.00009267697,0.00007574578,0.00001252167,0.0004111924,0.0003295651,0.00032697,0.0001539744,0.00003848945,0.000008129282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002736125,"about_ca_system_score_gemma":0.00005799087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002107283,"about_ca_topic_score_gemma":0.000004598322,"domain_scores_codex":[0.9987098,0.00003932918,0.0002510319,0.0002785956,0.0004231421,0.0002980851],"domain_scores_gemma":[0.9992759,0.0001006367,0.00009245858,0.0003291979,0.0001124929,0.00008934565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000374167,0.000006812264,0.000777433,0.00006175861,0.000003516423,7.315241e-7,0.001013668,0.02309418,0.974611,0.0003549554,0.000006144856,0.00003239953],"study_design_scores_gemma":[0.0001669195,0.0000734264,0.003915044,0.00009209474,0.00001556801,0.000008584501,0.0002277627,0.004222885,0.9911225,0.00001896159,0.00002698831,0.0001092206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989714,0.0001628429,0.00006769501,0.0002116601,0.0002676911,0.0002619988,0.00002003001,0.00002695238,0.00000972294],"genre_scores_gemma":[0.9995236,0.000005738993,0.0003629636,0.00004904213,0.0000216084,0.000009474904,3.416116e-7,0.00001250678,0.00001467982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0188713,"threshold_uncertainty_score":0.3088823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005142162390914054,"score_gpt":0.1821556829600363,"score_spread":0.1770135205691223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}