{"id":"W2914417447","doi":"10.1073/pnas.1817376116","title":"Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Novo Nordisk Fonden; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; Université Laval; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Antimicrobial; Antimicrobial peptides; Paneth cell; Degradation (telecommunications); Differential (mechanical device); Chemistry; Defensin; Microbiology; Cell biology; Biology; Biochemistry; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254433,0.0001184606,0.0002069767,0.0001100904,0.0002423566,0.00002247184,0.0003354804,0.0001436854,0.00005645517],"category_scores_gemma":[0.00005414162,0.00007995776,0.00006497997,0.0001808916,0.0009129098,0.0004174536,0.0001886571,0.0001971605,0.00001043001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002142819,"about_ca_system_score_gemma":0.00002223124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004125215,"about_ca_topic_score_gemma":3.30656e-7,"domain_scores_codex":[0.9991709,0.0000121555,0.0002391008,0.0002525801,0.000160263,0.0001650299],"domain_scores_gemma":[0.9993924,0.00009127764,0.0003864598,0.000008695409,0.0001099681,0.00001120758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005380293,0.00005786184,0.0057389,0.00005610257,0.00002655609,1.894633e-9,0.0003046813,0.000005538438,0.9884134,0.004211708,0.0007294132,0.0004020377],"study_design_scores_gemma":[0.0004035088,0.00006282425,0.05965266,0.00007688451,0.0000203787,0.0000075086,0.0003502053,0.00002997806,0.9369572,0.002139204,0.0002014338,0.00009821377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973974,0.00006070983,0.000001836877,0.0005585345,0.0000893825,0.0001886282,0.00004244967,0.000008557767,0.001652555],"genre_scores_gemma":[0.998524,0.00004991378,0.0002295416,0.0001514211,0.00002791375,0.000001745075,0.000002381134,0.000004514413,0.001008565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05391376,"threshold_uncertainty_score":0.3363654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508709379583087,"score_gpt":0.2485841123063339,"score_spread":0.2334970185105031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}