{"id":"W2914417447","doi":"10.1073/pnas.1817376116","title":"Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Novo Nordisk Fonden; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; Université Laval; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Antimicrobial; Antimicrobial peptides; Paneth cell; Degradation (telecommunications); Differential (mechanical device); Chemistry; Defensin; Microbiology; Cell biology; Biology; Biochemistry; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122936,0.0001349432,0.0001048773,0.0001322536,0.00007917971,0.0002136497,0.00006617742,0.0002104227,0.001184971],"category_scores_gemma":[0.0001266765,0.00005415978,0.0001752245,0.00009217927,0.0001468737,0.0002136939,0.0001482333,0.0003130477,0.0001975667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053418,"about_ca_system_score_gemma":0.00005211935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001597042,"about_ca_topic_score_gemma":0.0001458923,"domain_scores_codex":[0.9999056,0.00001248338,0.00001038708,0.00002654486,0.00002218339,0.00002286981],"domain_scores_gemma":[0.999893,0.00001755743,0.00002940793,0.00001379397,0.00001233969,0.00003382566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001416512,0.000007681282,0.0008674913,0.00001710008,0.000004103538,0.00003491285,0.00001397551,0.00001172122,0.9979649,0.0000206055,0.000008296857,0.0009077066],"study_design_scores_gemma":[0.000007869507,0.00033657,0.03030732,0.000006200389,0.00001462257,0.0007378299,0.00007808724,0.0002787832,0.9665054,0.00004561321,0.001678171,0.00000354837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974437,0.00095891,0.000856214,0.00002854779,0.000007200871,0.000007252324,0.00023419,0.000009094319,0.0004549231],"genre_scores_gemma":[0.9971169,0.0002090018,0.001035166,0.00003735666,0.000003258904,0.000005350062,0.0005418624,0.000003208897,0.001047869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184971,"threshold_uncertainty_score":0.003964126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508709379583087,"score_gpt":0.2485841123063339,"score_spread":0.2334970185105031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}