{"id":"W2914433592","doi":"10.1038/s41388-019-0730-9","title":"TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells","year":2019,"lang":"en","type":"article","venue":"Oncogene","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Natural Science Foundation of Zhejiang Province; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; National Natural Science Foundation of China","keywords":"TMPRSS2; Erg; Cancer research; Biology; Soluble guanylyl cyclase; Prostate cancer; Nitric oxide; Signal transduction; Enzalutamide; Carcinogenesis; Effector; Cell biology; Cancer; Endocrinology; Internal medicine; Guanylate cyclase; Medicine; Biochemistry; Genetics; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001810776,0.0001476621,0.0003035347,0.0001094634,0.00001997517,0.00001100198,0.00006706134,0.00006737959,0.000873561],"category_scores_gemma":[0.0000304778,0.000121108,0.00006648026,0.0002348808,0.00001609482,0.00006975986,0.00003016723,0.0001853674,0.001246003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203381,"about_ca_system_score_gemma":0.0001288544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003533461,"about_ca_topic_score_gemma":0.00001314377,"domain_scores_codex":[0.9989959,0.00003316452,0.0001943022,0.0002615835,0.0001925583,0.0003224899],"domain_scores_gemma":[0.9994497,0.0001034533,0.0000617263,0.0002204356,0.00006239701,0.0001023115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002717244,0.00008718936,0.02564376,0.0001555606,0.00003388066,0.00007245223,0.0001706204,0.0002231471,0.9651233,0.000003418249,0.0004515033,0.007763468],"study_design_scores_gemma":[0.002484381,0.0002227631,0.001400854,0.0003034227,0.00003472413,0.000009214818,0.00006102082,0.0004340599,0.9822075,0.00002064488,0.01265541,0.0001659572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992693,0.0007781719,0.000004004962,0.0002618144,0.0004311422,0.0005187345,0.00001050034,0.00004572868,0.005256918],"genre_scores_gemma":[0.9891048,0.0003520348,0.0004649545,0.0005295359,0.0002692447,0.00004347568,0.00001071084,0.0000370554,0.009188202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02424291,"threshold_uncertainty_score":0.9995316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007922097769718804,"score_gpt":0.2644501247732104,"score_spread":0.2565280270034916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}