{"id":"W2914433592","doi":"10.1038/s41388-019-0730-9","title":"TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells","year":2019,"lang":"en","type":"article","venue":"Oncogene","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Natural Science Foundation of Zhejiang Province; U.S. Department of Defense; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; National Natural Science Foundation of China","keywords":"TMPRSS2; Erg; Cancer research; Biology; Soluble guanylyl cyclase; Prostate cancer; Nitric oxide; Signal transduction; Enzalutamide; Carcinogenesis; Effector; Cell biology; Cancer; Endocrinology; Internal medicine; Guanylate cyclase; Medicine; Biochemistry; Genetics; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127378,0.0001783912,0.0002454589,0.0001467483,0.0001220415,0.0001871403,0.00008179989,0.0001795227,0.0007892216],"category_scores_gemma":[0.00007089462,0.00007686252,0.0001854438,0.0001782835,0.00012309,0.00009801637,0.0001284422,0.0004352001,0.0001878775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000210328,"about_ca_system_score_gemma":0.0002628448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001498103,"about_ca_topic_score_gemma":0.002587187,"domain_scores_codex":[0.99989,0.00002978077,0.000005745134,0.00001602341,0.00002856106,0.00002984993],"domain_scores_gemma":[0.99997,0.000006693403,0.000004908584,0.000003380148,0.000004201122,0.00001093219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106172,0.00006889173,0.0003768366,0.00005051559,0.000006250923,0.000117369,0.00002567007,0.0001064949,0.9975521,0.0001252859,0.0001675864,0.001192386],"study_design_scores_gemma":[0.0001205771,0.001393252,0.03827055,0.0000185768,0.00003497243,0.0009303204,0.0001662567,0.004024561,0.9452107,0.0002085438,0.009606619,0.0000151769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990576,0.004371484,0.001216523,0.0003270551,0.00006958122,0.00002844545,0.0005737361,0.00005679996,0.002780284],"genre_scores_gemma":[0.9961495,0.001152554,0.0004645633,0.0001125785,0.0000131079,0.00002314667,0.0005087661,0.00000306416,0.001572809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498103,"threshold_uncertainty_score":0.002978742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007922097769718804,"score_gpt":0.2644501247732104,"score_spread":0.2565280270034916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}