{"id":"W2914452574","doi":"10.1177/1740774518824539","title":"Challenges and solutions in the design and execution of the PROSPECT Phase II/III neoadjuvant rectal cancer trial (NCCTG N1048/Alliance)","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Medicine; Colorectal cancer; FOLFOX; Oxaliplatin; Oncology; Neoadjuvant therapy; Clinical trial; Clinical endpoint; Randomized controlled trial; Internal medicine; Surgery; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00892259,0.0001737088,0.001118892,0.00003224507,0.00009069868,0.00001358862,0.0001287142,0.0001947311,0.00009235392],"category_scores_gemma":[0.003760066,0.00008599008,0.0002805143,0.0001776305,0.0002859596,0.00006239757,0.0001066487,0.0003423985,0.000003123226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006950585,"about_ca_system_score_gemma":0.0002068517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005341536,"about_ca_topic_score_gemma":0.0000642016,"domain_scores_codex":[0.9959179,0.001917119,0.001169462,0.0004388254,0.0003107751,0.0002458882],"domain_scores_gemma":[0.9940429,0.005002838,0.0004038963,0.000389724,0.00006281453,0.00009781995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2664855,0.00598069,0.007013865,0.0001592237,0.0006923648,0.00003840899,0.002463799,0.00001843452,0.002097673,0.001558077,0.001285685,0.7122062],"study_design_scores_gemma":[0.7010859,0.03984835,0.2320502,0.001844607,0.001789962,0.00007166409,0.0008325209,0.001230183,0.002059413,0.00669341,0.01189694,0.0005968119],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741163,0.01272006,0.00001594809,0.005410385,0.001035463,0.005647333,0.00001756576,0.00001776657,0.001019193],"genre_scores_gemma":[0.98405,0.01458733,0.0001085595,0.0001800951,0.0004835352,0.0003254766,0.000002465202,0.00001191614,0.0002506456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7116094,"threshold_uncertainty_score":0.4501422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4787653320178136,"score_gpt":0.5176457104897636,"score_spread":0.03888037847195003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}