{"id":"W2914452574","doi":"10.1177/1740774518824539","title":"Challenges and solutions in the design and execution of the PROSPECT Phase II/III neoadjuvant rectal cancer trial (NCCTG N1048/Alliance)","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Medicine; Colorectal cancer; FOLFOX; Oxaliplatin; Oncology; Neoadjuvant therapy; Clinical trial; Clinical endpoint; Randomized controlled trial; Internal medicine; Surgery; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.6309,0.001603695,0.003319162,0.001580432,0.00260661,0.007429332,0.006279842,0.005318551,0.005750075],"category_scores_gemma":[0.4955724,0.001889354,0.003178556,0.002557439,0.00821693,0.005783675,0.005244073,0.01165914,0.00237968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004619963,"about_ca_system_score_gemma":0.02719522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002339624,"about_ca_topic_score_gemma":0.004754324,"domain_scores_codex":[0.2721206,0.6827197,0.02067681,0.007072988,0.01497346,0.00243641],"domain_scores_gemma":[0.5335396,0.3305534,0.04493421,0.04864159,0.02984156,0.01248955],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06075542,0.004168962,0.02781104,0.009686874,0.003014967,0.0008173819,0.01131658,0.02313141,0.004123027,0.1322267,0.09629145,0.6266562],"study_design_scores_gemma":[0.05832656,0.04501436,0.04031079,0.01565071,0.00280989,0.001325669,0.004171417,0.04164745,0.006951167,0.362049,0.420775,0.000967942],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.06991765,0.01749236,0.4399499,0.2398135,0.01409738,0.1823254,0.003502614,0.001231529,0.03166962],"genre_scores_gemma":[0.214169,0.002514181,0.4529548,0.06004027,0.004577179,0.2618536,0.001323769,0.0005029184,0.002064242],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.6309,"threshold_uncertainty_score":0.455166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4787653320178136,"score_gpt":0.5176457104897636,"score_spread":0.03888037847195003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}