{"id":"W2914471889","doi":"10.1158/1538-7445.prca2017-a041","title":"Abstract A041: LSD1 inhibition disrupts FOXA1-dependent AR cistrome","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"FOXA1; Transcription factor; Androgen receptor; Enhancer; Chromatin; Biology; Demethylase; Cancer research; Pioneer factor; Epigenetics; Epigenomics; Histone; Epigenome; Cell biology; Prostate cancer; Genetics; DNA methylation; Gene; Gene expression; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888181,0.0003713916,0.0004235473,0.0003381188,0.0003737946,0.000359996,0.0004779589,0.0004742779,0.008316805],"category_scores_gemma":[0.0001014484,0.0001905948,0.0006925057,0.000193646,0.000473796,0.0002339613,0.0003180923,0.001160252,0.001659257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007037712,"about_ca_system_score_gemma":0.0007059412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002783361,"about_ca_topic_score_gemma":0.003022012,"domain_scores_codex":[0.9997868,0.00002194822,0.00002349503,0.00005439914,0.00004902205,0.0000644465],"domain_scores_gemma":[0.999878,0.00001293577,0.00002681655,0.00001213397,0.00001066608,0.00005947822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071094,0.0002757982,0.0003822438,0.0001615783,0.00003521497,0.0001880868,0.00003191034,0.0002357059,0.9918724,0.0006009524,0.001594092,0.003550894],"study_design_scores_gemma":[0.0001638391,0.0009396884,0.002783871,0.00001480238,0.00004459028,0.0003389232,0.00005532209,0.001830173,0.9825019,0.0001882233,0.01112105,0.00001748806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735931,0.003468242,0.005043737,0.00104457,0.0005992597,0.0001005487,0.006305526,0.001002851,0.008842193],"genre_scores_gemma":[0.9863678,0.0007914337,0.001454297,0.0002148372,0.00002394702,0.00008261886,0.001901107,0.00007553402,0.009088377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008316805,"threshold_uncertainty_score":0.02782249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1255638966123337,"score_gpt":0.4711247264731977,"score_spread":0.345560829860864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}