{"id":"W2914496384","doi":"10.1158/2326-6074.cricimteatiaacr18-a147","title":"Abstract A147: AO-176, a next-generation anti-CD47 antibody, induces immunogenic cell death","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"CD47; Immunogenic cell death; Innate immune system; Immune system; Antibody; Acquired immune system; Immunology; Cytotoxic T cell; Immunotherapy; Cancer immunotherapy; Antigen; Biology; Programmed cell death; Dendritic cell; Phagocytosis; Cancer research; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001307818,0.0003918996,0.0006548704,0.0005984424,0.0006953842,0.0001274236,0.0009169157,0.0008974802,0.005064921],"category_scores_gemma":[0.00008199138,0.000362626,0.0002220729,0.0006380377,0.000557423,0.0006392781,0.0004042709,0.001620961,0.00516815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443616,"about_ca_system_score_gemma":0.0006310061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248474,"about_ca_topic_score_gemma":0.00002759851,"domain_scores_codex":[0.996164,0.0007308882,0.0006777618,0.000878698,0.0001972633,0.001351368],"domain_scores_gemma":[0.9978384,0.0002752626,0.0002521852,0.001058959,0.0005320507,0.00004313749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002208987,0.0002443148,0.008485528,0.00004477073,0.0003811696,0.000004850594,0.0003569323,0.0000277794,0.9784523,0.0003579781,0.001609793,0.009813651],"study_design_scores_gemma":[0.002305902,0.0003637434,0.2170991,0.00008504446,0.00003247261,0.00004037124,0.0003690117,0.00003954594,0.759304,0.0001307022,0.0198279,0.0004021195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9169378,0.07634506,0.000008427794,0.0004487622,0.002308427,0.0008158588,0.00003644855,0.00009974994,0.002999526],"genre_scores_gemma":[0.9861411,0.007777844,0.00002250848,0.00008262861,0.0001704075,0.0001667711,0.0005213243,0.00006444388,0.005053004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2191483,"threshold_uncertainty_score":0.9998826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201706260438329,"score_gpt":0.3780008427254079,"score_spread":0.257830216681575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}