{"id":"W2914496384","doi":"10.1158/2326-6074.cricimteatiaacr18-a147","title":"Abstract A147: AO-176, a next-generation anti-CD47 antibody, induces immunogenic cell death","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"CD47; Immunogenic cell death; Innate immune system; Immune system; Antibody; Acquired immune system; Immunology; Cytotoxic T cell; Immunotherapy; Cancer immunotherapy; Antigen; Biology; Programmed cell death; Dendritic cell; Phagocytosis; Cancer research; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193594,0.0003075773,0.0001756583,0.0001923199,0.00008782685,0.0001515288,0.0001707352,0.0003674492,0.003664305],"category_scores_gemma":[0.00009481647,0.00009991479,0.0001806234,0.00009297467,0.0001334243,0.0001266743,0.0001075138,0.0005384294,0.0007731926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045295,"about_ca_system_score_gemma":0.0001582419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002223674,"about_ca_topic_score_gemma":0.000175633,"domain_scores_codex":[0.999862,0.00002108345,0.00001169585,0.00001881108,0.00005147142,0.00003490351],"domain_scores_gemma":[0.9999261,0.00001848467,0.00001751767,0.000008631396,0.00001234736,0.00001681316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009713759,0.00004862225,0.00007979225,0.00002126119,0.00000348014,0.00004076536,0.000003317912,0.00004250537,0.9986179,0.00006585872,0.0001111999,0.0008682009],"study_design_scores_gemma":[0.00001892161,0.0003711865,0.0008592067,0.000001608068,0.000004562953,0.0002222504,0.000003151563,0.0004110688,0.9965006,0.00001485255,0.001591377,0.000001225717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986984,0.001686478,0.004641725,0.0002446193,0.0001113607,0.0000842102,0.0004610406,0.0001507312,0.005635847],"genre_scores_gemma":[0.9888757,0.0006079323,0.004129223,0.0002036784,0.00003076982,0.00005033093,0.0007653073,0.00001649607,0.005320563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003664305,"threshold_uncertainty_score":0.01225835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201706260438329,"score_gpt":0.3780008427254079,"score_spread":0.257830216681575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}