{"id":"W2914522618","doi":"10.1101/554907","title":"The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Toronto; McMaster University; Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; Oklahoma Center for the Advancement of Science and Technology; Presbyterian Health Foundation","keywords":"Apoptosis; Mutant; Mitochondrion; Cell biology; Bcl-xL; Bcl-2-associated X protein; Chemistry; Membrane; Sequence (biology); Bacterial outer membrane; Molecular biology; Biochemistry; Programmed cell death; Biology; Caspase 3; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891195,0.0002380366,0.0001944819,0.0001609187,0.0001819081,0.0002791521,0.0002516401,0.0001755294,0.00360015],"category_scores_gemma":[0.0002306006,0.0001189063,0.0001361414,0.0001240997,0.0002851847,0.0001789196,0.0002967635,0.0006181658,0.001014737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250941,"about_ca_system_score_gemma":0.0002915587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002291665,"about_ca_topic_score_gemma":0.000264253,"domain_scores_codex":[0.999805,0.00004375778,0.00001937061,0.00003402657,0.00005461837,0.00004314546],"domain_scores_gemma":[0.9998419,0.0000369896,0.00002167181,0.00002557922,0.0000143438,0.00005953356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099829,0.00002279441,0.00003081314,0.00001306744,0.000001164029,0.00002369905,0.000005722483,0.00003007305,0.9992014,0.0002300626,0.00002492237,0.0003063551],"study_design_scores_gemma":[0.00001590191,0.00009819965,0.0003637625,0.000002397224,0.000002690561,0.00009908382,0.00000516828,0.0003541496,0.997361,0.00003976219,0.001656157,0.000001617042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910336,0.0005974545,0.004779511,0.0001282227,0.00008141498,0.00003994381,0.0005161972,0.00009713897,0.002726448],"genre_scores_gemma":[0.9895574,0.0002337947,0.004188746,0.00005739365,0.00002109571,0.0000553441,0.001353791,0.00005179154,0.004480542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00360015,"threshold_uncertainty_score":0.01204371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010829209644808,"score_gpt":0.2142890999005808,"score_spread":0.2034598902557728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}