{"id":"W2914594769","doi":"10.18433/jpps30237","title":"Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Microsome; In vivo; Cytochrome P450; In vitro; Metabolism; Microsoma; Internal medicine; Endocrinology; Pharmacology; Chemistry; Biology; Biochemistry; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132923,0.0003341291,0.0002123918,0.0002717203,0.000119623,0.0002144199,0.0001175419,0.0001932539,0.0004947326],"category_scores_gemma":[0.0003703647,0.0001923061,0.0002519538,0.0001125082,0.0001632974,0.0001610493,0.0001007661,0.0003689528,0.0001915628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600175,"about_ca_system_score_gemma":0.000258776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002049483,"about_ca_topic_score_gemma":0.002183912,"domain_scores_codex":[0.9998722,0.00002242672,0.00001179499,0.0000394546,0.0000385259,0.00001564276],"domain_scores_gemma":[0.9997287,0.00004878849,0.00009773245,0.00003270927,0.00003875479,0.00005333874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001209274,0.0001093634,0.00965693,0.00002025502,0.00002529346,0.0000650803,0.00002385146,0.0007638117,0.985201,0.00008294514,0.00003274291,0.002809464],"study_design_scores_gemma":[0.00005559543,0.001424352,0.02872682,0.000001427168,0.00004500997,0.0001965518,0.00003055613,0.00694062,0.9621379,0.0000615714,0.0003631769,0.00001646856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949378,0.00009975066,0.004448312,0.00001692164,0.000004154917,0.0000172627,0.0002298789,0.00003224198,0.0002137307],"genre_scores_gemma":[0.9935536,0.00017316,0.004874596,0.00001953294,0.000002993349,0.00004464893,0.0005759466,0.00001516592,0.0007403201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049483,"threshold_uncertainty_score":0.00407517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1081882376641633,"score_gpt":0.4098067367442046,"score_spread":0.3016184990800413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}