{"id":"W2914614874","doi":"10.1038/s41598-018-37666-5","title":"Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; McGill University","keywords":"EIF4E; PI3K/AKT/mTOR pathway; Translation (biology); Initiation factor; Eukaryotic translation; In vivo; Protein biosynthesis; Biology; Cell biology; RNA Helicase A; Cancer research; RNA; Chemistry; Helicase; Messenger RNA; Biochemistry; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007702312,0.0002161424,0.0001170816,0.0001142026,0.00006459886,0.0001256749,0.00009696835,0.0001310032,0.001166627],"category_scores_gemma":[0.00004053674,0.00004835366,0.00013688,0.00007836836,0.0001281251,0.0001159022,0.0001028883,0.0002564799,0.0001980102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409634,"about_ca_system_score_gemma":0.0001021895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001654326,"about_ca_topic_score_gemma":0.0002607696,"domain_scores_codex":[0.999967,0.000006288582,0.000003262448,0.000008280276,0.000006275725,0.000008950194],"domain_scores_gemma":[0.9999611,0.000007364981,0.00001481393,0.000004622604,0.000004810315,0.000007348241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001430436,0.00002907735,0.00007455239,0.00004709356,0.000004179696,0.00002996822,0.000005346733,0.00008131755,0.9975691,0.0001258323,0.00001854137,0.001871852],"study_design_scores_gemma":[0.00001673159,0.0008532724,0.0009744147,0.000003796546,0.000006449796,0.0001083771,0.000007272547,0.0001829926,0.9954972,0.00004078656,0.002306436,0.000002253545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908097,0.002761823,0.002684467,0.00007008477,0.00004395684,0.00003401519,0.0002611737,0.000052349,0.003282508],"genre_scores_gemma":[0.9947588,0.001421943,0.001612645,0.00005282609,0.000009386259,0.00001683418,0.0002597103,0.000006360735,0.001861499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166627,"threshold_uncertainty_score":0.003902793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155147737374495,"score_gpt":0.2398325787339288,"score_spread":0.2243178049964793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}