{"id":"W2914668309","doi":"10.5772/intechopen.80702","title":"Prion Protein Strain Diversity and Disease Pathology","year":2019,"lang":"en","type":"book-chapter","venue":"IntechOpen eBooks","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsches Zentrum für Neurodegenerative Erkrankungen; Helmholtz-Alberta Initiative; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Scrapie; Prion protein; Pathogenesis; Biology; Glycosylation; Phenotype; Disease; Strain (injury); Virology; Allele; Genetics; Gene; Pathology; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008848195,0.0002559864,0.0002614355,0.0005556933,0.0001859376,0.001269358,0.0002947643,0.0003541653,0.006983797],"category_scores_gemma":[0.00009184777,0.0001198996,0.0001173766,0.0007986915,0.0003263742,0.0008359621,0.000466091,0.0005562378,0.003811895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876036,"about_ca_system_score_gemma":0.0001454599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003656649,"about_ca_topic_score_gemma":0.000562629,"domain_scores_codex":[0.9999526,0.0000047189,0.000002096033,0.00001457874,0.00002112288,0.000004909187],"domain_scores_gemma":[0.9999725,0.000009338948,0.000002843423,0.000002636368,0.000005432689,0.000007232537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001598869,0.00007227529,0.001415366,0.001079852,0.00002262235,0.001097532,0.0008167331,0.0009908276,0.07604414,0.1093328,0.05923565,0.7497324],"study_design_scores_gemma":[0.000008337714,0.0001225521,0.00748283,0.0004181629,0.00002103828,0.004614451,0.0002379772,0.0004806672,0.0064713,0.06253052,0.9175884,0.00002379817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.033383,0.5624675,0.004149851,0.002001185,0.0009364182,0.00003038755,0.0004360924,0.0001919576,0.3964036],"genre_scores_gemma":[0.1358179,0.4013678,0.004221578,0.0009548681,0.001177676,0.0000367648,0.0007375279,0.0001111725,0.4555748],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006983797,"threshold_uncertainty_score":0.02336311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496738491600779,"score_gpt":0.2270408334424779,"score_spread":0.2120734485264701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}