{"id":"W2914685386","doi":"10.1016/j.jaci.2019.02.003","title":"A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency","year":2019,"lang":"en","type":"letter","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institutes of Health","keywords":"Immunodeficiency; Primary immunodeficiency; Inflammation; Immunology; Medicine; Allergy; Human immunodeficiency virus (HIV); Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001068546,0.0007916302,0.001853338,0.0004714928,0.0005551868,0.00009659873,0.0008003397,0.002878448,0.000393191],"category_scores_gemma":[0.0004221322,0.0006163054,0.0004207215,0.0003191112,0.001900808,0.0004012313,0.0003016349,0.005596671,0.0001192072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007018798,"about_ca_system_score_gemma":0.0005430162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001232683,"about_ca_topic_score_gemma":0.00001794139,"domain_scores_codex":[0.9945201,0.001076035,0.002542687,0.0007471241,0.0001952257,0.0009188334],"domain_scores_gemma":[0.9948597,0.001409409,0.002418161,0.0007084737,0.0005807871,0.00002347391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007110528,0.004649135,0.004854057,0.000528698,0.04023942,0.0007323978,0.002841835,0.000125786,0.03357122,0.00274138,0.8357325,0.06687309],"study_design_scores_gemma":[0.008742644,0.006794535,0.007028356,0.0003244391,0.0003842943,0.001850765,0.0005736067,0.000006210237,0.0001892145,0.0003559673,0.9728089,0.0009410497],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5918437,0.265339,0.0003507881,0.1326173,0.006299861,0.0008661336,0.00008607442,0.000129999,0.002467069],"genre_scores_gemma":[0.6317098,0.1927892,0.0001514802,0.1389508,0.0005820263,0.00008864859,0.001917542,0.0005123987,0.03329816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1370765,"threshold_uncertainty_score":0.9996288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009337285986315377,"score_gpt":0.2435228519652873,"score_spread":0.2341855659789719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}