{"id":"W2914720861","doi":"10.1016/j.colsurfb.2019.02.011","title":"One-step preparation of gold nanovectors using folate modified polyethylenimine and their use in target-specific gene transfection","year":2019,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Polyethylenimine; Transfection; HeLa; Cytotoxicity; Gene delivery; Folate receptor; Molecular biology; Genetic enhancement; Cancer cell; Chemistry; Cell culture; Biology; Cell biology; Cancer research; Cell; In vitro; Cancer; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003229364,0.0004591545,0.0003269509,0.0002606748,0.0002159471,0.0002633164,0.0003246413,0.0004330224,0.000716186],"category_scores_gemma":[0.0004449942,0.0002313577,0.000254582,0.0002343744,0.0002264085,0.0002732789,0.0002518047,0.0004428673,0.0005015456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004060724,"about_ca_system_score_gemma":0.0002960217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051212,"about_ca_topic_score_gemma":0.001959372,"domain_scores_codex":[0.999797,0.00002924402,0.00002882912,0.00004990884,0.00005871457,0.00003622413],"domain_scores_gemma":[0.9998662,0.00003935466,0.00002647992,0.00002394987,0.00002870254,0.00001524066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002348026,0.000007411051,0.00003217391,0.00003783313,0.000004096587,0.00003201704,0.00002664713,0.00005603801,0.9975521,0.0001529125,0.00002686345,0.002048545],"study_design_scores_gemma":[0.000002336097,0.00003637266,0.0001582619,0.000001506386,0.000003469825,0.00004220501,0.000003671656,0.0002005673,0.9985009,0.00001875108,0.001028108,0.000003781558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.877951,0.003154018,0.1127664,0.000185145,0.0001188228,0.0005439799,0.0005743142,0.0005371886,0.004169167],"genre_scores_gemma":[0.911316,0.001580779,0.07888038,0.0000711955,0.00001271155,0.0002827146,0.0006850739,0.00007668254,0.007094415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051212,"threshold_uncertainty_score":0.002946258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229610909128689,"score_gpt":0.2435879400254999,"score_spread":0.220626849112631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}