{"id":"W2914774683","doi":"10.3389/fgene.2019.00130","title":"Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Rimouski; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Mitochondrial DNA; Biology; Mitochondrion; Nuclear gene; Genome; Nuclear DNA; Genetics; DNA damage; Gene; Human mitochondrial genetics; Cell biology; Oxidative stress; Phenotype; Reactive oxygen species; DNAJA3; mitochondrial fusion; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009057759,0.0001590128,0.000259818,0.0000831593,0.0000245979,0.00001405634,0.0001344239,0.0003212504,0.0000365951],"category_scores_gemma":[0.00003449344,0.000166388,0.00005917359,0.00008548934,0.00005632945,0.000003741907,0.00008257315,0.0001301945,0.000008170453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001112298,"about_ca_system_score_gemma":0.00003297092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002216496,"about_ca_topic_score_gemma":0.00001899495,"domain_scores_codex":[0.9988869,0.0001013208,0.0002815728,0.0003826313,0.0001375896,0.0002099263],"domain_scores_gemma":[0.9994541,0.000006417744,0.0001020224,0.000324606,0.00004121548,0.00007167517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002671013,0.00004718269,0.008307805,0.00001658681,0.00003565859,0.0000017181,0.00009454813,0.00005157318,0.9763789,0.00001452195,0.01211133,0.002673084],"study_design_scores_gemma":[0.004750947,0.0008153145,0.007325825,0.0000188743,0.00007133726,0.00001770318,0.0004830172,0.0003617531,0.77242,0.0002288902,0.2129895,0.000516826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870378,0.002662238,0.004389711,0.00004106359,0.004904728,0.0003506773,0.00002727897,0.000007496595,0.0005789918],"genre_scores_gemma":[0.9675669,0.00146435,0.02666194,0.0003374218,0.0005643219,0.00002477694,0.0001959589,0.00006020307,0.003124126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2039589,"threshold_uncertainty_score":0.6785104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006220707182724459,"score_gpt":0.2103599381462052,"score_spread":0.2041392309634807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}