{"id":"W2914774683","doi":"10.3389/fgene.2019.00130","title":"Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Rimouski; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Mitochondrial DNA; Biology; Mitochondrion; Nuclear gene; Genome; Nuclear DNA; Genetics; DNA damage; Gene; Human mitochondrial genetics; Cell biology; Oxidative stress; Phenotype; Reactive oxygen species; DNAJA3; mitochondrial fusion; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009688611,0.000376993,0.0001942567,0.0002303777,0.0001191834,0.0001809177,0.0001705912,0.0002850064,0.0007458733],"category_scores_gemma":[0.00008083472,0.0001174222,0.0001975051,0.0001083741,0.0001970484,0.0002210525,0.0002688222,0.0003586363,0.0001200722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694527,"about_ca_system_score_gemma":0.0001062942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003654701,"about_ca_topic_score_gemma":0.0005786546,"domain_scores_codex":[0.9999076,0.00001240909,0.00001265332,0.00002992245,0.00002143001,0.00001594513],"domain_scores_gemma":[0.9998606,0.00001237388,0.00006608119,0.00001855862,0.00001306461,0.00002922511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005580402,0.000007254982,0.0004726827,0.00001304832,0.000003855114,0.00006115303,0.000008894893,0.00001822791,0.9989927,0.00004641146,0.000006633147,0.0003132393],"study_design_scores_gemma":[0.000005651261,0.0003400456,0.02508223,0.000005444984,0.00002092885,0.0006271258,0.00004800736,0.0005706257,0.9723103,0.0001314433,0.000851548,0.000006512072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995306,0.001013108,0.002770289,0.00004124151,0.00002170187,0.00001724894,0.0002644442,0.00004942001,0.0005166524],"genre_scores_gemma":[0.9969221,0.000382322,0.001498281,0.0000202509,0.00000431981,0.00001382184,0.0002380782,0.00000834511,0.0009124979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007458733,"threshold_uncertainty_score":0.00249517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006220707182724459,"score_gpt":0.2103599381462052,"score_spread":0.2041392309634807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}