{"id":"W2914789585","doi":"10.1111/jcmm.14172","title":"Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells","year":2019,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Autophagy; TFEB; Endocrinology; Lipid droplet; Internal medicine; Lipid metabolism; Adipose tissue; Biology; Cell biology; Apoptosis; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003519628,0.0001040822,0.000295421,0.00009525922,0.00001201597,0.000004644313,0.00006524484,0.0001058706,0.00002200783],"category_scores_gemma":[0.00009359363,0.00006811602,0.00002998215,0.00008978594,0.00006311296,0.000007487433,0.00003110096,0.00008066188,2.853347e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003704002,"about_ca_system_score_gemma":0.00003824769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002827277,"about_ca_topic_score_gemma":9.086322e-7,"domain_scores_codex":[0.9992334,0.00006709611,0.0002796164,0.0001255844,0.0001827958,0.0001115498],"domain_scores_gemma":[0.9994311,0.00002122134,0.0002409258,0.0001142129,0.0001257869,0.00006676497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084268,0.00003406269,0.007577781,0.00004003058,0.00005936481,0.000007032597,0.0001321209,0.000008857032,0.9910474,0.000004471422,0.00006702617,0.0009134334],"study_design_scores_gemma":[0.001469123,0.0007119073,0.01253965,0.0002280338,0.00007068294,0.000006389761,0.00005472195,0.00007807075,0.9818935,0.00001029377,0.002857833,0.00007973419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948893,0.004529277,0.0001784714,0.0001056482,0.0001318906,0.00008070045,0.00000151225,0.000001055621,0.00008215272],"genre_scores_gemma":[0.9991179,0.000364791,0.0001536844,0.0001690273,0.00009126303,3.033204e-7,0.000013793,0.00001079439,0.00007849613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009153831,"threshold_uncertainty_score":0.2777691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006842160105892243,"score_gpt":0.2308535494624402,"score_spread":0.2240113893565479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}