{"id":"W2914800037","doi":"10.1101/542837","title":"Cholesterol sensing by CD81 is important for hepatitis C virus entry","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust","keywords":"CD81; Allosteric regulation; Cholesterol; Chemistry; Mutant; Receptor; Cell biology; Hepatitis C virus; Biochemistry; Biology; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006867552,0.0002181984,0.000285036,0.00008254295,0.0005893192,0.0005279374,0.0001874325,0.0003937461,0.002381762],"category_scores_gemma":[0.0002420784,0.0001412049,0.0002506122,0.0001123272,0.0002937308,0.0004451208,0.0002775714,0.0003162599,0.0002760224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004345156,"about_ca_system_score_gemma":0.0005552613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003781635,"about_ca_topic_score_gemma":0.003180637,"domain_scores_codex":[0.999934,0.00001065031,0.000003356238,0.00001031745,0.00001874684,0.00002298232],"domain_scores_gemma":[0.999958,0.000009316219,0.000009159844,0.000004518216,0.000008314822,0.00001065913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010545,0.0002768638,0.02025203,0.0004250024,0.000141243,0.000996348,0.0004036762,0.1623138,0.7720991,0.02102651,0.001582609,0.01947227],"study_design_scores_gemma":[0.000294927,0.0006996088,0.04341214,0.00007395542,0.0001909657,0.0006108385,0.0007428837,0.7570809,0.1693266,0.01386419,0.01355719,0.0001458969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918091,0.0005352763,0.003194611,0.0002159134,0.0000318661,0.00001430845,0.00007238411,0.00005040047,0.004076062],"genre_scores_gemma":[0.9980804,0.0003109246,0.0009377495,0.00004218929,0.000004205056,0.00001101966,0.00008476301,0.00001215652,0.0005166127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003781635,"threshold_uncertainty_score":0.00796783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178353208171349,"score_gpt":0.2667080539679355,"score_spread":0.2488727331508006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}