{"id":"W2914802931","doi":"10.3389/fmicb.2019.00049","title":"Signal Transduction Proteins in Acinetobacter baumannii: Role in Antibiotic Resistance, Virulence, and Potential as Drug Targets","year":2019,"lang":"en","type":"review","venue":"Frontiers in Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba; Cystic Fibrosis Foundation","keywords":"Acinetobacter baumannii; Virulence; Biology; Drug resistance; Antibiotics; Antibiotic resistance; Pathogen; Drug; Microbiology; Phenotype; Signal transduction; Computational biology; Bacteria; Genetics; Gene; Pharmacology; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003603314,0.0007404223,0.0009782265,0.001770681,0.0002308721,0.0008194595,0.00054147,0.0009974164,0.001972077],"category_scores_gemma":[0.0003775188,0.0002480004,0.0004093908,0.001692211,0.0004144729,0.001048501,0.0005382849,0.001644411,0.001299626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000593001,"about_ca_system_score_gemma":0.0008976289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008365987,"about_ca_topic_score_gemma":0.001336279,"domain_scores_codex":[0.999881,0.00001798091,0.00001769836,0.0000195983,0.00004676636,0.00001697632],"domain_scores_gemma":[0.9998099,0.00008074467,0.00002978512,0.000004745474,0.000053648,0.00002119788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001126857,0.00007515884,0.0001857094,0.02275853,0.0000732888,0.0002748127,0.00008697693,0.0005986842,0.01015022,0.005104185,0.0191198,0.94146],"study_design_scores_gemma":[0.00001482735,0.0001471576,0.001021346,0.002837568,0.00009344419,0.001190955,0.00007484023,0.0001614523,0.001640547,0.002169735,0.9906254,0.00002263105],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001509208,0.9989244,0.00009206786,0.0001680155,0.0001481295,0.000001735199,0.000009300698,0.000003877777,0.0005015578],"genre_scores_gemma":[0.000705681,0.9985321,0.0001252158,0.0001017769,0.0001012645,0.000002977249,0.00002095046,8.619481e-7,0.000409222],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001972077,"threshold_uncertainty_score":0.006597281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006121763803834909,"score_gpt":0.2364620955944666,"score_spread":0.2303403317906317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}