{"id":"W2914834617","doi":"10.1001/jamapsychiatry.2018.4166","title":"Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population","year":2019,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of Mental Health; Statens Serum Institut; Campbell Family Mental Health Research Institute; SUNY Downstate Medical Center; Veterans Affairs San Diego Healthcare System; University of Illinois at Urbana-Champaign; H. Lundbeck A/S; Assistance publique-Hôpitaux de Paris; Rheinische Friedrich-Wilhelms-Universität Bonn; Montreal Neurological Institute and Hospital; Tartu Ülikool; Diakonhjemmet; NIH Clinical Center; Göteborgs Universitet; Ludwig-Maximilians-Universität München; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Háskóli Íslands; Johns Hopkins Bloomberg School of Public Health; Universitetet i Bergen; Umeå Universitet; University of Queensland; Karolinska Institutet; Universitair Medisch Centrum Utrecht; U.S. Department of Veterans Affairs; University of Pennsylvania; Technische Universität Dresden; Westfälische Wilhelms-Universität Münster; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Trinity College Dublin; Universitat de Barcelona; King's College London; Dalhousie University; Universitätsmedizin Göttingen; Bundesinstitut für Arzneimittel und Medizinprodukte; Norges Teknisk-Naturvitenskapelige Universitet; McGill University Health Centre; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Broad Institute; School of Medicine, Indiana University; University of New South Wales; University of Pittsburgh; National University of Ireland; Vanderbilt University Medical Center; Vrije Universiteit Amsterdam; Universitat Autònoma de Barcelona; Neuroscience Research Australia; Universidad de Granada; Aarhus Universitetshospital; University of North Carolina at Chapel Hill; Queen Mary University of London; University of Worcester; McGill University; QIMR Berghofer Medical Research Institute; Aarhus Universitet; Universität Basel; Università di Bologna; University of Aberdeen; Universitätsklinikum Köln; Massachusetts General Hospital; University of Minnesota; University College London; Lundbeckfonden; Cardiff University; Universiteit Antwerpen; State University of New York; Vanderbilt University; Brigham and Women's Hospital; University of California, Los Angeles; Pfizer; Eberhard Karls Universität Tübingen; McDonnell Center for Systems Neuroscience; University of California, San Diego; Université Paris Diderot; Universitetet i Oslo; Johns Hopkins University; Rush University; Amgen; University of Southern California; University of Toronto","keywords":"Depression (economics); Bipolar disorder; Schizophrenia (object-oriented programming); Danish; Psychiatry; Polygenic risk score; Association (psychology); Psychology; Population; Medicine; Major depressive disorder; Clinical psychology; Genotype; Genetics; Single-nucleotide polymorphism; Mood; Biology; Environmental health; Psychotherapist; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001323979,0.0002289437,0.0003166059,0.0008046125,0.0006569899,0.0006339641,0.0003238178,0.0003044208,0.001134059],"category_scores_gemma":[0.003120155,0.0003235087,0.000648533,0.0008545247,0.0003630814,0.0001917618,0.0005944984,0.0003279452,0.00008632841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005738851,"about_ca_system_score_gemma":0.0008340557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05670195,"about_ca_topic_score_gemma":0.061006,"domain_scores_codex":[0.9988324,0.0003166176,0.0001711123,0.0003804586,0.0001689428,0.0001304229],"domain_scores_gemma":[0.9984419,0.0003510625,0.0005992673,0.0002884681,0.0001517264,0.0001675611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001026689,0.00001448791,0.9974378,0.00001866175,0.0002845023,0.00007133752,0.00009617243,0.0001737553,0.0003317931,0.0001134017,0.0001494347,0.00120584],"study_design_scores_gemma":[0.000006563599,0.00002274581,0.9990429,0.000008234843,0.0000728654,0.0001251216,0.00009376022,0.0003276122,0.00003321301,0.00009292975,0.0001684759,0.000005548874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973405,0.000545901,0.0004433027,0.00007169625,0.000008765633,0.000008532652,0.001164813,0.000004806327,0.0004116062],"genre_scores_gemma":[0.9988678,0.0001704053,0.0002022592,0.00001035497,0.000003427857,0.000006435844,0.000611964,0.000001569618,0.0001258911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05670195,"threshold_uncertainty_score":0.1127439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003354655145965356,"score_gpt":0.2296067116938665,"score_spread":0.2262520565479011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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