{"id":"W2914834617","doi":"10.1001/jamapsychiatry.2018.4166","title":"Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population","year":2019,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of Mental Health; Statens Serum Institut; Campbell Family Mental Health Research Institute; SUNY Downstate Medical Center; Veterans Affairs San Diego Healthcare System; University of Illinois at Urbana-Champaign; H. Lundbeck A/S; Assistance publique-Hôpitaux de Paris; Rheinische Friedrich-Wilhelms-Universität Bonn; Montreal Neurological Institute and Hospital; Tartu Ülikool; Diakonhjemmet; NIH Clinical Center; Göteborgs Universitet; Ludwig-Maximilians-Universität München; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Háskóli Íslands; Johns Hopkins Bloomberg School of Public Health; Universitetet i Bergen; Umeå Universitet; University of Queensland; Karolinska Institutet; Universitair Medisch Centrum Utrecht; U.S. Department of Veterans Affairs; University of Pennsylvania; Technische Universität Dresden; Westfälische Wilhelms-Universität Münster; School of Medicine, Stanford University; Institut National de la Santé et de la Recherche Médicale; Trinity College Dublin; Universitat de Barcelona; King's College London; Dalhousie University; Universitätsmedizin Göttingen; Bundesinstitut für Arzneimittel und Medizinprodukte; Norges Teknisk-Naturvitenskapelige Universitet; McGill University Health Centre; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Broad Institute; School of Medicine, Indiana University; University of New South Wales; University of Pittsburgh; National University of Ireland; Vanderbilt University Medical Center; Vrije Universiteit Amsterdam; Universitat Autònoma de Barcelona; Neuroscience Research Australia; Universidad de Granada; Aarhus Universitetshospital; University of North Carolina at Chapel Hill; Queen Mary University of London; University of Worcester; McGill University; QIMR Berghofer Medical Research Institute; Aarhus Universitet; Universität Basel; Università di Bologna; University of Aberdeen; Universitätsklinikum Köln; Massachusetts General Hospital; University of Minnesota; University College London; Lundbeckfonden; Cardiff University; Universiteit Antwerpen; State University of New York; Vanderbilt University; Brigham and Women's Hospital; University of California, Los Angeles; Pfizer; Eberhard Karls Universität Tübingen; McDonnell Center for Systems Neuroscience; University of California, San Diego; Université Paris Diderot; Universitetet i Oslo; Johns Hopkins University; Rush University; Amgen; University of Southern California; University of Toronto","keywords":"Depression (economics); Bipolar disorder; Schizophrenia (object-oriented programming); Danish; Psychiatry; Polygenic risk score; Association (psychology); Psychology; Population; Medicine; Major depressive disorder; Clinical psychology; Genotype; Genetics; Single-nucleotide polymorphism; Mood; Biology; Environmental health; Psychotherapist; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006651458,0.0001062467,0.0001690765,0.0000374224,0.00009828782,0.00001505359,0.0001108595,0.0002321286,0.00000295485],"category_scores_gemma":[0.0003191368,0.00007368337,0.00007028104,0.00006474925,0.0000164523,0.000007757834,0.00002686635,0.00007919335,3.897706e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001273113,"about_ca_system_score_gemma":0.00004077681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001977736,"about_ca_topic_score_gemma":0.001143039,"domain_scores_codex":[0.9990695,0.0001429703,0.0002616213,0.0002615341,0.00008571187,0.0001786663],"domain_scores_gemma":[0.999172,0.0001650062,0.0003275221,0.0002401636,0.00007477399,0.00002057308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003591475,0.00005215033,0.9952292,0.0000488363,0.00004393845,4.624504e-9,0.00005237234,0.0001241191,0.0007889177,0.00007695176,0.001120805,0.002103552],"study_design_scores_gemma":[0.002638283,0.0002827811,0.9912717,0.00002267252,0.00005833872,0.000001058409,0.000332906,0.0004354623,0.0001264079,0.001837998,0.002887252,0.000105147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932864,0.00303421,0.001877348,0.0007228095,0.0001889608,0.0007454843,0.0001152388,0.000004377912,0.00002511449],"genre_scores_gemma":[0.9900178,0.000185514,0.008969883,0.0001376754,0.0001550485,0.0001324449,0.0002269272,0.00001550733,0.0001592467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007092535,"threshold_uncertainty_score":0.3004721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003354655145965356,"score_gpt":0.2296067116938665,"score_spread":0.2262520565479011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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