{"id":"W2914966474","doi":"10.1074/jbc.aw118.003236","title":"Dynamic structural biology at the protein membrane interface","year":2019,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Membrane biology; Function (biology); Computational biology; Structural biology; Signal transduction; Chemistry; Biology; Cell biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004622417,0.0004343257,0.001097464,0.00003081872,0.00009210972,0.0000309006,0.0007386471,0.0009486417,0.0003608336],"category_scores_gemma":[0.0002782626,0.0002192245,0.0009008001,0.0001070935,0.0002666065,0.000003333683,0.0004082279,0.0006328865,0.00002423136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001068995,"about_ca_system_score_gemma":0.0002283856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.955184e-7,"about_ca_topic_score_gemma":4.857966e-7,"domain_scores_codex":[0.9980162,0.0002381337,0.0008928858,0.0003948435,0.0001491297,0.0003087863],"domain_scores_gemma":[0.9979693,0.00005583046,0.001259844,0.0004547929,0.0001456651,0.0001145092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001801232,0.00004044838,0.000007048112,0.004120275,0.0005227471,0.00002195007,0.000006100969,0.00002407481,0.7801203,0.00001364741,0.0003133318,0.2146299],"study_design_scores_gemma":[0.0002850186,0.0002118653,0.000001284067,0.001312965,0.000157441,0.0008097341,0.000009595038,0.000006007075,0.07177894,0.00004661458,0.9250582,0.0003223286],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01607693,0.9828423,0.0001221396,0.00005968658,0.0001717017,0.0004014198,0.00006911953,0.000006872547,0.0002498806],"genre_scores_gemma":[0.01313927,0.9837959,0.0002261027,0.00004391789,0.0004710598,0.00002110881,0.0003056905,0.00003628429,0.00196066],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9247448,"threshold_uncertainty_score":0.8939717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232208137122312,"score_gpt":0.3242788526893295,"score_spread":0.2919567713181064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}