{"id":"W2914988374","doi":"10.3324/haematol.2018.207837","title":"ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms","year":2019,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Bijzonder Onderzoeksfonds UGent; Universiteit Gent; Vlaamse regering; National Health and Medical Research Council; Swiss Bridge Foundation; European Hematology Association","keywords":"Biology; Cancer research; Progenitor cell; Transcription factor; Haematopoiesis; Cell biology; Cellular differentiation; Stem cell; Leukemia; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571522,0.0003103252,0.0001999511,0.0003411884,0.0001525779,0.0004676992,0.00020179,0.0002384883,0.001272928],"category_scores_gemma":[0.0001165522,0.0001850309,0.0001532421,0.0001811692,0.0003060367,0.0002369547,0.0003800959,0.0007605971,0.0003322379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004146727,"about_ca_system_score_gemma":0.0002554313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004431154,"about_ca_topic_score_gemma":0.0009396963,"domain_scores_codex":[0.9997389,0.00004355414,0.00002706129,0.00004312508,0.00008043981,0.00006696954],"domain_scores_gemma":[0.9998438,0.0000269239,0.00004959351,0.00001740267,0.00000799497,0.00005420101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009837597,0.00004450391,0.0003045475,0.00001320323,0.000002874171,0.00004908113,0.00002381959,0.00006048931,0.9981585,0.0005597202,0.00002569749,0.0006591468],"study_design_scores_gemma":[0.00005484088,0.0003519431,0.003082841,0.000004551568,0.00001676263,0.0004765563,0.00005846105,0.001439146,0.9904733,0.0001300055,0.003906881,0.00000477023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941099,0.0003993575,0.002861925,0.00006871453,0.00001163501,0.000058623,0.0003138643,0.00008443918,0.00209169],"genre_scores_gemma":[0.9937077,0.0003385399,0.002037785,0.00004849913,0.000006976888,0.00007793186,0.0004688738,0.00003910831,0.003274516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272928,"threshold_uncertainty_score":0.004258335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007954733886676247,"score_gpt":0.2392221660847568,"score_spread":0.2312674321980806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}