{"id":"W2914988374","doi":"10.3324/haematol.2018.207837","title":"ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms","year":2019,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Bijzonder Onderzoeksfonds UGent; Universiteit Gent; Vlaamse regering; National Health and Medical Research Council; Swiss Bridge Foundation; European Hematology Association","keywords":"Biology; Cancer research; Progenitor cell; Transcription factor; Haematopoiesis; Cell biology; Cellular differentiation; Stem cell; Leukemia; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000273918,0.0004476487,0.0009644104,0.0001791266,0.0001508415,0.00005363856,0.0003155693,0.0005039222,0.001170911],"category_scores_gemma":[0.0002399272,0.0003214513,0.0001866192,0.0003584801,0.0002359238,0.0001053913,0.0003898969,0.0005036444,0.002418142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008823026,"about_ca_system_score_gemma":0.0006946984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005730112,"about_ca_topic_score_gemma":0.000005069389,"domain_scores_codex":[0.9970385,0.0001138923,0.0004772641,0.0008503391,0.0006921282,0.0008278915],"domain_scores_gemma":[0.9978681,0.0005578851,0.0001845823,0.0007553027,0.0001639304,0.0004702315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01170477,0.00171079,0.0249631,0.006592816,0.001290745,0.01824369,0.002210159,0.00008966171,0.8591,0.0274663,0.03356864,0.01305928],"study_design_scores_gemma":[0.09985559,0.01902512,0.1872125,0.003690968,0.003514141,0.1045192,0.004108607,0.1476123,0.3358339,0.05652631,0.03035254,0.007748825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777815,0.0005536146,0.005897926,0.0004840161,0.0002769613,0.001201352,0.00002056246,0.0002641646,0.01351992],"genre_scores_gemma":[0.9908987,0.00008137402,0.003992826,0.0006579059,0.00008066795,0.00006572493,0.00005416104,0.00006749683,0.004101166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5232661,"threshold_uncertainty_score":0.9999238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007954733886676247,"score_gpt":0.2392221660847568,"score_spread":0.2312674321980806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}