{"id":"W2915001443","doi":"10.1002/stem.2978","title":"Regulation of von Willebrand Factor Gene in Endothelial Cells That Are Programmed to Pluripotency and Differentiated Back to Endothelial Cells","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Houston Methodist Research Institute; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Cancer Research Society; Heart and Stroke Foundation of Canada","keywords":"Biology; Endothelial stem cell; Cell biology; Induced pluripotent stem cell; Chromatin; Vasculogenesis; Epigenetics; Vascular endothelial growth factor B; Umbilical vein; Cellular differentiation; Von Willebrand factor; Molecular biology; Stem cell; Embryonic stem cell; Immunology; Vascular endothelial growth factor A; Cancer research; Genetics; Vascular endothelial growth factor; Gene; In vitro; Progenitor cell; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007299487,0.0002311873,0.0003072647,0.00009800647,0.00002518183,0.00002541081,0.0001451414,0.0002303988,0.00007583587],"category_scores_gemma":[0.000002062835,0.0001903595,0.00009108439,0.0001335949,0.00003770709,0.000006577957,0.00008990311,0.00009268273,0.0000762585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002837695,"about_ca_system_score_gemma":0.00003932098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005640212,"about_ca_topic_score_gemma":0.0000350225,"domain_scores_codex":[0.9986345,0.00006980068,0.0003010973,0.0004754266,0.0001920058,0.0003271676],"domain_scores_gemma":[0.9993663,0.00001193371,0.0001456195,0.0002597034,0.00005644652,0.0001599353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004007326,0.00005319299,0.002730575,0.0001046547,0.00004535872,0.000001908724,0.0002780345,0.0002890184,0.9930304,0.000001121208,0.0001910877,0.002873863],"study_design_scores_gemma":[0.001465831,0.0003909109,0.003839458,0.00009951959,0.00001532033,0.000001768997,0.00007109611,0.00004577581,0.9891689,0.000006842728,0.004652729,0.0002418129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975436,0.0001772786,0.00009947109,0.00006152444,0.0005575626,0.001039323,0.0002611294,0.000008860859,0.000251243],"genre_scores_gemma":[0.9941596,0.000247333,0.0001583141,0.00007661452,0.00009148661,0.00001867363,0.0000312673,0.00003200807,0.005184694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004933451,"threshold_uncertainty_score":0.7762637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007483799307367682,"score_gpt":0.2013236033031248,"score_spread":0.1938398039957571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}