{"id":"W2915001443","doi":"10.1002/stem.2978","title":"Regulation of von Willebrand Factor Gene in Endothelial Cells That Are Programmed to Pluripotency and Differentiated Back to Endothelial Cells","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Houston Methodist Research Institute; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Cancer Research Society; Heart and Stroke Foundation of Canada","keywords":"Biology; Endothelial stem cell; Cell biology; Induced pluripotent stem cell; Chromatin; Vasculogenesis; Epigenetics; Vascular endothelial growth factor B; Umbilical vein; Cellular differentiation; Von Willebrand factor; Molecular biology; Stem cell; Embryonic stem cell; Immunology; Vascular endothelial growth factor A; Cancer research; Genetics; Vascular endothelial growth factor; Gene; In vitro; Progenitor cell; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101355,0.0001431267,0.0001536198,0.0001777338,0.00008627838,0.000248637,0.00009407805,0.0001473223,0.0006740016],"category_scores_gemma":[0.0001251932,0.0001020447,0.0001971978,0.0001499199,0.0001573609,0.0001208579,0.0001527108,0.000327352,0.0001505117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787741,"about_ca_system_score_gemma":0.000130844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657373,"about_ca_topic_score_gemma":0.0005938686,"domain_scores_codex":[0.9998361,0.00001858524,0.00001573151,0.0000510302,0.0000517494,0.00002681717],"domain_scores_gemma":[0.9998981,0.00001456627,0.00003087258,0.00001450293,0.00002221303,0.00001976542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000208929,0.000005470152,0.0003588979,0.00001151496,0.000003020113,0.00001818341,0.00001361984,0.00001747971,0.9984136,0.0001053796,0.00001231571,0.00101973],"study_design_scores_gemma":[0.000005688675,0.0001316748,0.02185841,0.000004250304,0.00001676807,0.0001674018,0.00003015951,0.000552005,0.9744725,0.00008211367,0.002675119,0.000003921072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931031,0.00160669,0.003520512,0.00004337147,0.00003332988,0.00002084887,0.0004994014,0.00004998972,0.001122642],"genre_scores_gemma":[0.9923317,0.000720542,0.002877413,0.00008376894,0.000009996887,0.00002838642,0.0008880255,0.00001337206,0.003046642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006740016,"threshold_uncertainty_score":0.002254784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007483799307367682,"score_gpt":0.2013236033031248,"score_spread":0.1938398039957571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}