{"id":"W2915022564","doi":"10.1038/s41467-018-06958-9","title":"CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Jewish General Hospital; University of Ottawa; Montreal Children's Hospital; Ottawa Hospital; McGill University; McGill University Health Centre","funders":"Congressionally Directed Medical Research Programs; Fondation Gustave Roussy; Canadian HIV Trials Network, Canadian Institutes of Health Research; Government of Canada; Canadian Institutes of Health Research; Institut Gustave-Roussy; Cancer Research Society; U.S. Department of Defense; McGill University; Faculty of Medicine, McGill University; Cancer Research Institute","keywords":"Ovary; Cancer research; Cyclin D1; Biology; Cyclin D; Cell biology; Medicine; Internal medicine; Cell cycle; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657507,0.0001070761,0.0001217252,0.00004063297,0.00006694777,0.000006689043,0.0009681212,0.0002828848,0.00001166694],"category_scores_gemma":[0.00005890867,0.00008553879,0.0001082268,0.0001905326,0.0000860293,0.00000267682,0.0004309323,0.0004514841,0.000005018555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002653504,"about_ca_system_score_gemma":0.0001377756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005971318,"about_ca_topic_score_gemma":0.0003001024,"domain_scores_codex":[0.9992102,0.0001125287,0.0002495852,0.000189681,0.00009393135,0.00014401],"domain_scores_gemma":[0.9980363,0.00004213999,0.0001076155,0.00171057,0.00007711907,0.00002620675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000242056,0.0001976809,0.1571534,0.00004571738,0.000006304321,1.394935e-7,0.0001895281,0.0003605568,0.8398068,0.0001021403,0.00167934,0.0004342104],"study_design_scores_gemma":[0.002679756,0.0002807803,0.2197821,0.0001917133,0.00005937313,0.00002366485,0.0005774878,0.00837805,0.7187094,0.0004422251,0.04810655,0.0007689561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833727,0.00968397,0.00001454683,0.0003771557,0.0002250674,0.0002271028,0.00002267899,0.000006660374,0.00607007],"genre_scores_gemma":[0.9970473,0.0001897468,0.001856463,0.0001881464,0.00003289606,0.00001679149,0.00008117574,0.00001550719,0.000571951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1210974,"threshold_uncertainty_score":0.3488171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033032981466079,"score_gpt":0.2481730047054103,"score_spread":0.2378426748907495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}