{"id":"W2915022564","doi":"10.1038/s41467-018-06958-9","title":"CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Jewish General Hospital; University of Ottawa; Montreal Children's Hospital; Ottawa Hospital; McGill University; McGill University Health Centre","funders":"Congressionally Directed Medical Research Programs; Fondation Gustave Roussy; Canadian HIV Trials Network, Canadian Institutes of Health Research; Government of Canada; Canadian Institutes of Health Research; Institut Gustave-Roussy; Cancer Research Society; U.S. Department of Defense; McGill University; Faculty of Medicine, McGill University; Cancer Research Institute","keywords":"Ovary; Cancer research; Cyclin D1; Biology; Cyclin D; Cell biology; Medicine; Internal medicine; Cell cycle; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108709,0.0002052404,0.0002452867,0.0003107693,0.000130899,0.0002187206,0.0002077763,0.000195169,0.001309164],"category_scores_gemma":[0.0001268869,0.0001264884,0.0001889772,0.0001885361,0.0002159706,0.00009477407,0.0001253134,0.0002903648,0.0001769644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003644844,"about_ca_system_score_gemma":0.0002630665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072699,"about_ca_topic_score_gemma":0.002201486,"domain_scores_codex":[0.9999378,0.000008741174,0.000007455519,0.00000964814,0.00001760745,0.00001864935],"domain_scores_gemma":[0.999939,0.00001399416,0.00001547608,0.00000789509,0.000005977861,0.00001769098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003323187,0.00007654124,0.0009872491,0.0000319583,0.000009848934,0.0002797422,0.000008186152,0.0002033199,0.9950128,0.0001398146,0.000100003,0.002818155],"study_design_scores_gemma":[0.00008059474,0.0006403874,0.006096481,0.000002735807,0.0000225292,0.0009084055,0.00002446354,0.0009981489,0.9888906,0.00007742963,0.002254915,0.000003214656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966021,0.0009693915,0.0007631697,0.0001226056,0.00002117669,0.00003976514,0.0002280644,0.00005676972,0.001197115],"genre_scores_gemma":[0.9977822,0.0004089498,0.0005625932,0.00002981815,0.00000502232,0.0000152716,0.0001685871,0.000008891598,0.001018738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309164,"threshold_uncertainty_score":0.00437957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033032981466079,"score_gpt":0.2481730047054103,"score_spread":0.2378426748907495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}