{"id":"W2915023124","doi":"10.1002/hep4.1305","title":"A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis","year":2019,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Cilag; Norgine; National Institute for Health and Care Research; Pfizer; NGM Biopharmaceuticals; Medical Research Council; Valeant Pharmaceuticals International; Intercept Pharmaceuticals; Gilead Sciences; GlaxoSmithKline; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ursodeoxycholic acid; Itching; Placebo; Medicine; Internal medicine; Gastroenterology; Biliary colic; Adverse effect; Randomized controlled trial; Bile acid; Confidence interval; Cholestasis; Surgery; Gallstones; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005630467,0.0001084739,0.001180833,0.0001209114,0.00006409326,0.000003982369,0.0003023331,0.00004917592,0.00003993043],"category_scores_gemma":[0.000133637,0.00005856171,0.0001747738,0.0002144066,0.0002088439,0.00004506121,0.00005275734,0.0001423849,0.000002748075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006784565,"about_ca_system_score_gemma":0.0001165973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542397,"about_ca_topic_score_gemma":0.0003146948,"domain_scores_codex":[0.9974534,0.001730077,0.0004778698,0.00009906592,0.00012971,0.0001098699],"domain_scores_gemma":[0.9958218,0.002294626,0.0002923138,0.00146097,0.0001050862,0.00002517092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.08225804,0.02889644,0.875082,0.00002894337,0.001545558,0.00001118953,0.01107454,0.000003136408,0.0001216884,0.0003431424,0.00002476601,0.000610556],"study_design_scores_gemma":[0.8249667,0.002937984,0.1646485,0.0001021865,0.001481471,0.00001780592,0.004591533,0.001021434,0.00001513881,0.00005569006,0.00008509716,0.00007648944],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903894,0.002352152,0.000003075691,0.0007359575,0.00001835226,0.003655048,0.00002046263,0.00001221725,0.002813303],"genre_scores_gemma":[0.9979947,0.001196047,0.00006747177,0.0001378045,0.00000278018,0.0003786189,0.0001345694,0.000008144716,0.00007991952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7427087,"threshold_uncertainty_score":0.2388077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330058336344865,"score_gpt":0.3249624798541945,"score_spread":0.2916618964907458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}