{"id":"W2915023124","doi":"10.1002/hep4.1305","title":"A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis","year":2019,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Cilag; Norgine; National Institute for Health and Care Research; Pfizer; NGM Biopharmaceuticals; Medical Research Council; Valeant Pharmaceuticals International; Intercept Pharmaceuticals; Gilead Sciences; GlaxoSmithKline; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ursodeoxycholic acid; Itching; Placebo; Medicine; Internal medicine; Gastroenterology; Biliary colic; Adverse effect; Randomized controlled trial; Bile acid; Confidence interval; Cholestasis; Surgery; Gallstones; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002044053,0.001616896,0.002901004,0.0004661428,0.0004345495,0.0008690357,0.0008256303,0.001781592,0.005871943],"category_scores_gemma":[0.002378373,0.0009145601,0.001378538,0.0003639284,0.0009348334,0.001022618,0.0003859607,0.002480572,0.0007984553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005149431,"about_ca_system_score_gemma":0.001175742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008364904,"about_ca_topic_score_gemma":0.002169351,"domain_scores_codex":[0.999166,0.0005102361,0.00004319258,0.0001160374,0.00005772744,0.0001067309],"domain_scores_gemma":[0.9991004,0.0003038009,0.0002009028,0.0000690367,0.00008952427,0.000236284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9715396,0.01299791,0.0003940046,0.0006013393,0.0006285056,0.00005219051,0.00005318162,0.0002501218,0.002684394,0.00009598763,0.0006219972,0.01008073],"study_design_scores_gemma":[0.9383817,0.05974312,0.0008440817,0.00001773941,0.0001605009,0.00002341691,0.00001294858,0.0002207693,0.0001722319,0.0000540999,0.0003614129,0.000007885218],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798111,0.003844819,0.001098922,0.0007194836,0.0008050456,0.0102048,0.001218839,0.0001873591,0.002109747],"genre_scores_gemma":[0.9713224,0.003869859,0.00318696,0.001497877,0.0006337133,0.01438443,0.001204075,0.00003998398,0.003860769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005871943,"threshold_uncertainty_score":0.01964366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330058336344865,"score_gpt":0.3249624798541945,"score_spread":0.2916618964907458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}