{"id":"W2915031663","doi":"10.1042/etls20180100","title":"Targeted therapies for congenital myasthenic syndromes: systematic review and steps towards a treatabolome","year":2019,"lang":"en","type":"article","venue":"Emerging Topics in Life Sciences","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Medical Research Council; Horizon 2020 Framework Programme; European Commission","keywords":"Medicine; Disease; Intensive care medicine; Genetic heterogeneity; Genetic testing; Life expectancy; Myasthenia gravis; Bioinformatics; Pathology; Internal medicine; Population; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008962207,0.0001510842,0.0006858375,0.0001424053,0.00008561472,0.00003010303,0.0001769475,0.00004508113,0.000126855],"category_scores_gemma":[0.0003369701,0.00009988378,0.00008395739,0.0003426609,0.0001436205,0.0001274794,0.00004147294,0.00008575671,0.00001233263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002040456,"about_ca_system_score_gemma":0.0001126831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003307281,"about_ca_topic_score_gemma":0.000008448955,"domain_scores_codex":[0.9986899,0.00006197341,0.0003998235,0.0003174558,0.0002618554,0.0002689211],"domain_scores_gemma":[0.999421,0.00008789466,0.0001080643,0.0002391776,0.00005425082,0.00008964096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001808154,0.0006073319,0.1759162,0.7312745,0.001235827,0.0000749011,0.01702276,0.00001253614,0.001134227,0.063988,0.00224526,0.00630765],"study_design_scores_gemma":[0.03209004,0.01845548,0.311027,0.4698908,0.00921832,0.002874307,0.04811794,0.0171703,0.001057739,0.02897453,0.05383684,0.007286772],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8537931,0.1371363,0.00003332504,0.005426939,0.0003064819,0.002204279,0.0000126668,0.00004364928,0.001043207],"genre_scores_gemma":[0.989758,0.004117895,0.001725308,0.001497881,0.00008368242,0.0001542356,0.00000627361,0.00001516824,0.002641614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2613838,"threshold_uncertainty_score":0.4073142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02974107018742648,"score_gpt":0.3144130428922664,"score_spread":0.2846719727048399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}