{"id":"W2915048372","doi":"10.2967/jnumed.118.220483","title":"<sup>18</sup>F-Branched-Chain Amino Acids: Structure–Activity Relationships and PET Imaging Potential","year":2019,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; TRIUMF; Simon Fraser University","funders":"TRIUMF","keywords":"Biodistribution; Amino acid; In vivo; Chemistry; Amino acid transporter; In vitro; Stereochemistry; Pet imaging; Transporter; Biochemistry; Positron emission tomography; Nuclear medicine; Biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982025,0.0002366429,0.00009729634,0.00009440237,0.00007335578,0.000150621,0.0001227289,0.0002997152,0.0005623941],"category_scores_gemma":[0.0001754389,0.00008962522,0.0001363405,0.0001236009,0.00012733,0.00023955,0.00005109484,0.0002525467,0.0001433544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724166,"about_ca_system_score_gemma":0.0001036484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008624343,"about_ca_topic_score_gemma":0.0009173003,"domain_scores_codex":[0.9999511,0.00001252975,0.000002461302,0.00001070119,0.00001061104,0.00001255401],"domain_scores_gemma":[0.9999149,0.00002531304,0.00002650506,0.000005220052,0.00002031866,0.000007843657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308659,0.00001359869,0.0003229384,0.00003811684,0.000003973251,0.00004076755,0.00001185477,0.0002519745,0.9968263,0.0001107152,0.00003736501,0.0022116],"study_design_scores_gemma":[0.000005053358,0.0003267991,0.001302297,0.000002288433,0.000008870672,0.0001479629,0.00001001457,0.0009874662,0.9957718,0.00002541079,0.001407541,0.000004337078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986139,0.004046494,0.007351752,0.0001224613,0.00001164497,0.00002560555,0.0001735365,0.00003655084,0.002092978],"genre_scores_gemma":[0.9867249,0.002401203,0.0090169,0.00006172504,0.000008932556,0.00002087489,0.0002589459,0.00001329541,0.001493228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008624343,"threshold_uncertainty_score":0.00197655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007677091204004394,"score_gpt":0.2292477037314419,"score_spread":0.2215706125274375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}