{"id":"W2915117294","doi":"10.1182/blood-2018-99-110363","title":"Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"GATA1; Haematopoiesis; Myeloid leukemia; Biology; Leukemia; Progenitor cell; Cancer research; Myeloid; Acute leukemia; Stem cell; CRISPR; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086866,0.0003326388,0.0002655689,0.0003082919,0.00019142,0.000434995,0.0005266952,0.000544432,0.001434139],"category_scores_gemma":[0.0002851936,0.0002319393,0.0004947914,0.0001347721,0.0002718017,0.0002490541,0.0004393551,0.0003769682,0.0001736031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004642112,"about_ca_system_score_gemma":0.0004298542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005632137,"about_ca_topic_score_gemma":0.003137,"domain_scores_codex":[0.9999405,0.000009834819,0.000004273043,0.0000186552,0.00001284271,0.00001387454],"domain_scores_gemma":[0.9999119,0.00003446072,0.00002248114,0.000006938625,0.00001005737,0.00001411566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008582563,0.00005585015,0.006195919,0.0001452561,0.00005043466,0.0005569027,0.0000616227,0.8975669,0.08324651,0.007401798,0.0003710977,0.004261854],"study_design_scores_gemma":[0.00001947248,0.00007478915,0.001480065,0.00001074135,0.00002960586,0.0001601856,0.00002957013,0.9810751,0.01246043,0.001772307,0.002871083,0.00001657096],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8095058,0.0009332123,0.1751351,0.0002536499,0.0001013639,0.0001299234,0.001482316,0.000901247,0.01155736],"genre_scores_gemma":[0.9571518,0.0005295541,0.03807017,0.00003723874,0.000008082651,0.0001250186,0.000467997,0.00006929191,0.003540816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005632137,"threshold_uncertainty_score":0.0111987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366271168343069,"score_gpt":0.3024676171566177,"score_spread":0.268804905473187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}