{"id":"W2915202693","doi":"10.1016/j.chom.2019.01.015","title":"Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Drug Applied Research Center, Tabriz University of Medical Sciences; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Staphylococcus aureus; Leukocidin; Biology; Hemolysin; Virulence; Lethality; Microbiology; Pathogenesis; Toxin; Chemokine; Endothelial stem cell; Immunology; Staphylococcal infections; Bacteria; Inflammation; Methicillin-resistant Staphylococcus aureus; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004773489,0.0005208204,0.0008633304,0.0003711334,0.00009088907,0.00006145702,0.0004940987,0.000311971,0.001085981],"category_scores_gemma":[0.0001315658,0.0005249137,0.000269496,0.0006964957,0.0001524515,0.0001455158,0.0002796194,0.0007293635,0.002788556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006052165,"about_ca_system_score_gemma":0.0004925077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007752842,"about_ca_topic_score_gemma":0.0004089525,"domain_scores_codex":[0.9966513,0.0001291598,0.0007228308,0.001005904,0.000396047,0.001094785],"domain_scores_gemma":[0.9979957,0.0001596635,0.0001894654,0.001024761,0.0002080619,0.0004222959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006709562,0.0003919072,0.046762,0.0002830663,0.00004162479,0.0002579729,0.001057509,0.00003384847,0.9336936,0.00005238856,0.01663668,0.0001183642],"study_design_scores_gemma":[0.003139573,0.0003069543,0.02462843,0.0002463773,0.00005879637,0.00001441991,0.0004064539,0.00001086827,0.8086671,0.00003036911,0.1619115,0.0005790746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808658,0.0005843016,0.0002824788,0.0009945204,0.0006906092,0.002044959,0.0003671978,0.000127576,0.01404254],"genre_scores_gemma":[0.9810071,0.00007864785,0.003839127,0.003076148,0.0002672995,0.00003637897,0.00007361554,0.0001180169,0.01150368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1452749,"threshold_uncertainty_score":0.9998271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228575760858724,"score_gpt":0.2649940828078786,"score_spread":0.2527083251992913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}