{"id":"W2915202693","doi":"10.1016/j.chom.2019.01.015","title":"Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Drug Applied Research Center, Tabriz University of Medical Sciences; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Staphylococcus aureus; Leukocidin; Biology; Hemolysin; Virulence; Lethality; Microbiology; Pathogenesis; Toxin; Chemokine; Endothelial stem cell; Immunology; Staphylococcal infections; Bacteria; Inflammation; Methicillin-resistant Staphylococcus aureus; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004518169,0.0008662331,0.0005002898,0.001238168,0.0003818324,0.0007039091,0.0006851485,0.001274756,0.003735103],"category_scores_gemma":[0.0003353947,0.0005391377,0.0008904926,0.0002746853,0.0007224263,0.0004845007,0.0003885144,0.003750461,0.001126306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009355944,"about_ca_system_score_gemma":0.0005515747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147075,"about_ca_topic_score_gemma":0.001809535,"domain_scores_codex":[0.9991593,0.0001320239,0.00006119631,0.0001744704,0.000212129,0.0002608085],"domain_scores_gemma":[0.9992236,0.0001157708,0.0002740593,0.00009269639,0.00005075077,0.0002431456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006645562,0.0004617116,0.0002137047,0.00004151283,0.00002069683,0.0002391207,0.00003983058,0.0002467703,0.9952449,0.0008698571,0.0003227999,0.001634562],"study_design_scores_gemma":[0.0003064026,0.002344103,0.002416715,0.00003520511,0.00005094705,0.000708642,0.0001029749,0.003195262,0.9861691,0.0002648694,0.004389036,0.00001689127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822072,0.001699642,0.007440544,0.001155655,0.000262192,0.0001588809,0.001462342,0.000578519,0.005035083],"genre_scores_gemma":[0.9818748,0.001272699,0.003530184,0.0005847709,0.00007516629,0.0001849931,0.001003327,0.0001746872,0.01129936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003735103,"threshold_uncertainty_score":0.01249516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228575760858724,"score_gpt":0.2649940828078786,"score_spread":0.2527083251992913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}