{"id":"W2915405957","doi":"10.1073/pnas.1815071116","title":"OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Cancer Society; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Azacitidine; Myeloid leukemia; Innate immune system; Biology; Drug; Cytotoxicity; Cancer research; Immune system; Pharmacology; DNA methylation; Immunology; Biochemistry; Gene; In vitro; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002698888,0.0001124476,0.0002492212,0.0001491693,0.0002087605,0.0000103717,0.001108871,0.0001123843,0.0001261149],"category_scores_gemma":[0.001148696,0.00005936883,0.000134754,0.0004803948,0.001378512,0.0002528848,0.0002901114,0.0003056229,0.00001736185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001885999,"about_ca_system_score_gemma":0.00005749675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002631189,"about_ca_topic_score_gemma":1.163249e-7,"domain_scores_codex":[0.9987913,0.00004861561,0.0005080902,0.0001855077,0.0002723627,0.0001941141],"domain_scores_gemma":[0.9983674,0.00055985,0.0007479944,0.00001816376,0.000298631,0.000007951616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008356839,0.00003978885,0.002677201,0.00003997794,0.00004237311,1.7644e-9,0.0007628907,0.000007177688,0.9803539,0.01554015,0.0001804792,0.0002725163],"study_design_scores_gemma":[0.0002778292,0.00007860112,0.03148156,0.0001160738,0.000008928339,0.000007367658,0.0008992223,0.00004516375,0.9627316,0.003947411,0.0003395873,0.00006668477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923892,0.001256937,1.90699e-7,0.001911763,0.00007989894,0.000225451,0.00002111348,0.000009569756,0.00410588],"genre_scores_gemma":[0.9985229,0.00004535394,0.00006331916,0.000173055,0.00001534293,0.000007155479,3.168167e-7,0.00000418604,0.001168421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02880435,"threshold_uncertainty_score":0.5079184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163603697445259,"score_gpt":0.2718279806892525,"score_spread":0.2501919437147999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}