{"id":"W2915405957","doi":"10.1073/pnas.1815071116","title":"OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Cancer Society; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Azacitidine; Myeloid leukemia; Innate immune system; Biology; Drug; Cytotoxicity; Cancer research; Immune system; Pharmacology; DNA methylation; Immunology; Biochemistry; Gene; In vitro; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832318,0.0003703043,0.0002648758,0.0001772876,0.0001586749,0.0002709634,0.0001244725,0.0002291728,0.002200114],"category_scores_gemma":[0.000122583,0.00009827608,0.000340929,0.00009942047,0.0002688299,0.0002125239,0.0001585523,0.0006746591,0.0004921854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004050163,"about_ca_system_score_gemma":0.0002797937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003759219,"about_ca_topic_score_gemma":0.0006290163,"domain_scores_codex":[0.9998555,0.00002851591,0.00001343849,0.00003166068,0.00003478094,0.00003598755],"domain_scores_gemma":[0.9998945,0.0000172242,0.00003175505,0.00001446095,0.0000125566,0.000029591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007919552,0.00001710489,0.000153881,0.00002010551,0.00000426276,0.00001583051,0.0000043689,0.00003809232,0.9990262,0.00006015617,0.00002187758,0.000558938],"study_design_scores_gemma":[0.00001185057,0.0002054775,0.002817166,0.000004112836,0.000006687237,0.0001107433,0.00001603998,0.0006171127,0.9951825,0.0000339443,0.000992569,0.000001852288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922498,0.001513145,0.003135481,0.0001617735,0.00004875589,0.00002711953,0.000389356,0.00006626217,0.002408392],"genre_scores_gemma":[0.9954069,0.0004046361,0.001259454,0.00004138481,0.0000093699,0.00002270096,0.0005318314,0.000006262783,0.002317486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200114,"threshold_uncertainty_score":0.00736016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163603697445259,"score_gpt":0.2718279806892525,"score_spread":0.2501919437147999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}