{"id":"W2915448739","doi":"10.1111/acel.12924","title":"Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Science Foundation Ireland","keywords":"Bioenergetics; Mitochondrion; Biology; NAD+ kinase; Glycolysis; Cell biology; Flux (metallurgy); Cytosol; Respiratory chain; Mitochondrial disease; Mitochondrial DNA; ATP–ADP translocase; Genetically modified mouse; Neurodegeneration; Alzheimer's disease; Transgene; Biochemistry; Metabolism; Chemistry; Inner mitochondrial membrane; Pathology; Disease; Gene; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156424,0.0004934721,0.0004455373,0.000228818,0.0002215634,0.0005127657,0.0003761282,0.0004281142,0.0005476382],"category_scores_gemma":[0.0003504461,0.0002000417,0.0005644721,0.0001938182,0.0003788235,0.0003367192,0.0004297778,0.0002579157,0.00005288279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006445094,"about_ca_system_score_gemma":0.0005292183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003532395,"about_ca_topic_score_gemma":0.002300763,"domain_scores_codex":[0.9999576,0.000009798466,0.000002496245,0.00001220294,0.00001061675,0.000007302471],"domain_scores_gemma":[0.9999132,0.00004326109,0.000014006,0.000008631416,0.00001152623,0.000009273016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009383209,0.00006824302,0.004914814,0.0001738198,0.000126688,0.0002461907,0.0000603489,0.9365814,0.0473136,0.005347445,0.0002313544,0.004842351],"study_design_scores_gemma":[0.0000119317,0.00004626373,0.001520909,0.000004568322,0.00002108896,0.00002555708,0.00001674671,0.9913414,0.004435688,0.002359604,0.000209263,0.00000698571],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9276554,0.0005017847,0.06737971,0.0002811583,0.00003974976,0.0000315118,0.0002401345,0.0004133739,0.003457248],"genre_scores_gemma":[0.9891521,0.0002025708,0.01014796,0.0000288148,0.000004332052,0.00003428673,0.0001325676,0.00002479787,0.0002726368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003532395,"threshold_uncertainty_score":0.007023692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166295490240509,"score_gpt":0.2564052658621628,"score_spread":0.2397757168381119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}