{"id":"W2915448739","doi":"10.1111/acel.12924","title":"Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons","year":2019,"lang":"en","type":"article","venue":"Aging Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Science Foundation Ireland","keywords":"Bioenergetics; Mitochondrion; Biology; NAD+ kinase; Glycolysis; Cell biology; Flux (metallurgy); Cytosol; Respiratory chain; Mitochondrial disease; Mitochondrial DNA; ATP–ADP translocase; Genetically modified mouse; Neurodegeneration; Alzheimer's disease; Transgene; Biochemistry; Metabolism; Chemistry; Inner mitochondrial membrane; Pathology; Disease; Gene; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201433,0.0001976789,0.0003542418,0.0001458457,0.00003088419,0.00002320321,0.000288799,0.0001620512,0.00004188814],"category_scores_gemma":[0.0001668779,0.000186631,0.0001786702,0.000167572,0.00005112684,0.000007120824,0.0001938583,0.0001690302,0.00008040386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009122253,"about_ca_system_score_gemma":0.0001016959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006510312,"about_ca_topic_score_gemma":0.0001287778,"domain_scores_codex":[0.9983552,0.0003620668,0.0003580826,0.0005295399,0.00008964701,0.0003055318],"domain_scores_gemma":[0.9989689,0.00005663841,0.0001191294,0.0006129555,0.00008266939,0.0001596892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002967826,0.00008995631,0.01719672,0.00006788825,0.00005458156,0.00001649594,0.0000776322,0.0003635176,0.9806279,0.0001345722,0.001022111,0.00005186292],"study_design_scores_gemma":[0.005934352,0.001224611,0.08907641,0.0002089261,0.0005875495,0.00007043625,0.0006383111,0.001408048,0.8532593,0.0004828266,0.0456418,0.001467467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922345,0.003254823,0.0007395676,0.0001034392,0.002377087,0.000741252,0.00006096627,0.00002031623,0.0004680265],"genre_scores_gemma":[0.9982837,0.00002880817,0.0002060736,0.0001724429,0.0001858134,0.00006587945,0.00009909684,0.00002495,0.0009332299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1273686,"threshold_uncertainty_score":0.761059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166295490240509,"score_gpt":0.2564052658621628,"score_spread":0.2397757168381119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}